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See detailVIP: Vortex Image Processing package for high-contrast direct imaging
Gómez González, Carlos ULg; Wertz, Olivier; Absil, Olivier ULg et al

in Astronomical Journal (The) (in press)

We present the Vortex Image Processing (VIP) library, a python package dedicated to astronomical high-contrast imaging. Our package relies on the extensive python stack of scientific libraries and aims to ... [more ▼]

We present the Vortex Image Processing (VIP) library, a python package dedicated to astronomical high-contrast imaging. Our package relies on the extensive python stack of scientific libraries and aims to provide a flexible framework for high-contrast data and image processing. In this paper, we describe the capabilities of VIP related to processing image sequences acquired using the angular di↵erential imaging (ADI) observing technique. VIP implements functionalities for building high-contrast data processing pipelines, encompass- ing pre- and post-processing algorithms, potential sources position and flux estimation, and sensitivity curves generation. Among the reference point-spread function subtraction techniques for ADI post-processing, VIP includes several flavors of principal component analysis (PCA) based algorithms, such as annular PCA and incremental PCA algorithm capable of processing big datacubes (of several gigabytes) on a computer with limited memory. Also, we present a novel ADI algorithm based on non-negative matrix factorization (NMF), which comes from the same family of low-rank matrix approximations as PCA and provides fairly similar results. We showcase the ADI capabilities of the VIP library using a deep sequence on HR8799 taken with the LBTI/LMIRCam and its recently commissioned L-band vortex coronagraph. Using VIP we investigated the presence of additional companions around HR8799 and did not find any significant additional point source beyond the four known planets. VIP is available at http://github.com/vortex-exoplanet/VIP and is accompanied with Jupyter notebook tutorials illustrating the main functionalities of the library. [less ▲]

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See detailIn San Carlo all’Arena district: positive and negative values in a degraded cultural landscape
Rapalo, Maria Chiara ULg

in Atti del Convegno Internazionale La Baia di Napoli. Strategie integrate per la conservazione e la fruizione del paesaggio culturale (in press)

Located in the 'inner periphery' of Neapolitan historic center, at the foot of Capodimonte Park, historically the urban fabric of San Carlo Arena district eastern area has developed around two ... [more ▼]

Located in the 'inner periphery' of Neapolitan historic center, at the foot of Capodimonte Park, historically the urban fabric of San Carlo Arena district eastern area has developed around two architectural complexes: Santa Maria dei Miracoli and Santa Maria degli Angeli alle Croci, for a long time aggregation places for local people. In addition, the ‘lava dei Vergini’ phenomenon, which periodically flooded the area outside the ancient city walls and the ‘for a via’ street (Via Foria), created optimal conditions for tuff extraction, used for local construction. In the past, physical features, such as the irregularity of the hilly area modeled by natural agents, the presence of several underground quarries, the grandeur of remarkable architectural presence, the numerous alleys in a heavily layered historical fabric, and the peculiarities of the social life that took place beyond Foria, have been a source of inspiration for several and also internationally renowned artists. The original identity of the ancient outer suburb, born from progressive expansions of the neighboring villages outside the city walls, is still marked. The closing elements that caracterize the architecture - in particular building fronts -, reflect its inhabitants attitudes and daily life. In this historic urban landscape 'shred’, this closure - despite the direct proximity to the adjacent old town and several, but not easily accessible, panoramic views of part of Naples Bay - continues to be one of the main identifying characters of the area. Although, for many centuries, this has allowed the 'spirit of places’ conservation, it has been transformed into a voluntary closure against the legality, which led to today serious state of neglect and social decay. Sometimes it is possible to find an excessive and illegal man-soil interaction, and unlawful activities influence and define some features of historical buildings in the area. However, for some years the local population has become aware of the existing problems by operating in a more concrete way, through different kinds of associations and volunteer that try to face the territory needs and emergencies. The goal is the elaboration of an update overview of the existing dynamics in this part of urban tissue and the identification of elements to take into account for possible enhancement perspectives in respect of an identity between invariant and processing factors. [less ▲]

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See detailLa grammaire du raisonnable. Ethnographie des pratiques interprétatives au Conseil d'Etat belge
Colemans, Julie ULg

in Colemans, Julie; Dupret, Baudouin (Eds.) Ethnographies du raisonnement juridique (in press)

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See detailDons de livres à Louise de Savoie
Fagnart, Laure ULg

in Heering, Caroline (Ed.) Le don mis en scène. Représentations visuelles et textuelles de l’acte de donation dans les arts de la première Modernité (in press)

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See detailPharmacokinetic characterization of [18F]UCB-H PET radiopharmaceutical in the rat brain.
Becker, Guillaume ULg; Warnier, Corentin; Serrano Navacerrada, Maria Elisa ULg et al

in Molecular Pharmaceutics (in press)

The synaptic vesicle glycoprotein 2A (SV2A), a protein essential to the proper nervous system function, is found in presynaptic vesicles. Thus, SV2A targeting, using dedicated radiotracers combined with ... [more ▼]

The synaptic vesicle glycoprotein 2A (SV2A), a protein essential to the proper nervous system function, is found in presynaptic vesicles. Thus, SV2A targeting, using dedicated radiotracers combined with positron emission tomography (PET), allows the assessment of synaptic density in the living brain. The first-in-class fluorinated SV2A specific radioligand, [18F]UCB-H, is now available at high-activity through an efficient radiosynthesis compliant with the current good manufacturing practices (cGMP). We report here a non-invasive method to quantify [18F]UCB-H binding in rat brain with microPET. Validation study in rats confirmed the need of high enantiomeric purity to target SV2A in vivo. We demonstrated the reliability of a population-based input function to quantify SV2A in preclinical microPET setting. Finally, we investigated the in vivo metabolism of [18F]UCB-H and confirmed the negligible amount of radiometabolites in the rat brain. Hence, the in vivo quantification of SV2A using [18F]UCB-H microPET seems a promising tool for the assessment of the synaptic density in the rat brain, and opens the way for longitudinal follow-up in neurodegenerative diseases rodents’ models. [less ▲]

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See detailMapping degenerate vortex states in a kagomé lattice of elongated antidots via scanning Hall probe microscopy
Xue, Cun; Ge, Jun-Yi; He, An et al

in Physical Review. B : Condensed Matter (in press)

We investigate the degeneracy of the superconducting vortex matter ground state by directly visualizing the vortex con gurations in a kagomé lattice of elongated antidots via scanning Hall probe ... [more ▼]

We investigate the degeneracy of the superconducting vortex matter ground state by directly visualizing the vortex con gurations in a kagomé lattice of elongated antidots via scanning Hall probe microscopy (SHPM). The observed vortex patterns, at specifi c applied magnetic fi elds, are in good agreement with the confi gurations obtained using time-dependent Ginzburg-Landau (TDGL) simulation. Both results indicate that the long range interaction in this nano-structured superconductor is unable to lift degeneracy between different vortex states and the pattern formation is mainly ruled by the nearest neighbour interaction. This simpli cation allows the identi cation of a set of simple rules characterizing the vortex con gurations. We demonstrated that these rules can explain both the observed vortex distributions and the magnetic fi eld dependent degree of degeneracy. [less ▲]

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See detailSepsis prediction in critically ill patients by platelet activation markers on ICU admission: a prospective pilot study
LAYIOS, Nathalie ULg; Delierneux, Céline ULg; Hego, Alexandre ULg et al

in Intensive Care Medicine Experimental (in press)

Background: Platelets have been involved in both surveillance and host defense against severe infection. To date, whether platelet phenotype or other hemostasis components could be associated with ... [more ▼]

Background: Platelets have been involved in both surveillance and host defense against severe infection. To date, whether platelet phenotype or other hemostasis components could be associated with predisposition to sepsis in critical illness remains unknown. The aim of this work was to identify platelet markers that could predict sepsis occurrence in critically ill injured patients. Results: This single-center, prospective, observational, 7-month study was based on a cohort of 99 non-infected adult patients admitted to ICUs for elective cardiac surgery, trauma, acute brain injury and post-operative prolonged ventilation and followed up during ICU stay. Clinical characteristics and severity score (SOFA) were recorded on admission. Platelet activation markers, including fibrinogen binding to platelets, platelet membrane P-selectin expression, plasma soluble CD40L, and platelet-leukocytes aggregates were assayed by flow cytometry at admission and 48h later, and also at the time of sepsis diagnosis (Sepsis-3 criteria) and 7 days later for sepsis patients. Hospitalization data and outcomes were also recorded. Of the 99 patients, 19 developed sepsis after a median time of 5 days. SOFA at admission was higher; their levels of fibrinogen binding to platelets (platelet-Fg) and of D-dimers were significantly increased compared to the other patients. Levels 48h after ICU admission were no longer significant. Platelet-Fg % was an independent predictor of sepsis (P = 0.030). By ROC curve analysis cutoff points for SOFA (AUC=0.85) and Platelet-Fg (AUC=0.75) were 8 and 50%, respectively. The prior risk of sepsis (19%) increased to 50% when SOFA was above 8, to 46% when Platelet-Fg was above 50%, and to 87% when both SOFA and Platelet-Fg were above their cutoff values. By contrast, when the two parameters were below their cutoffs, the risk of sepsis was negligible (3.8%). Patients with sepsis had longer ICU and hospital stays and higher death rate. Conclusion: In addition to SOFA, platelet-bound fibrinogen levels assayed by flow cytometry within 24h of ICU admission help identifying critically ill patients at risk of developing sepsis. [less ▲]

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See detailCrystal Structure and Kinetic Analysis of the Class B3 Di-Zinc Metallo-β-Lactamase LRA-12 from an Alaskan Soil Metagenome
Rodríguez, María Margarita; Herman, Raphaël ULg; Ghiglione, Barbara et al

in PLoS ONE (in press)

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See detailIncreased antimicrobial resistance in a novel CMY-54 AmpC-type enzyme with a GluLeu217-218 insertion in the Ω-loop
Pérez-Llarena, Francisco José; Vázquez-Ucha, Juan Carlos; Kerff, Frédéric ULg et al

in Microbial Drug Resistance : Mechanism, Epidemiology, & Disease (in press)

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See detailKülpe on Conscious Cognitive Attitudes
Dewalque, Arnaud ULg

in Discipline Filosofiche (in press)

This paper offers a reconstruction of Külpe’s theory of cognitive attitudes from the perspective of contemporary debates about cognitive phenomenology. I argue that, like Carl Stumpf at approximately the ... [more ▼]

This paper offers a reconstruction of Külpe’s theory of cognitive attitudes from the perspective of contemporary debates about cognitive phenomenology. I argue that, like Carl Stumpf at approximately the same time, Külpe endorses two major claims about cognitive experiences. First, cognitive experiences are best described in terms of cognitive acts, functions or attitudes. Second, cognitive attitudes are intransitively conscious in the sense that they are experienced by, or phenomenally manifest to, the subject. I call the combination of those two claims the conscious cognitive attitudes theory—or CCA for short. I introduce Külpe’s version of CCA, briefly present some rationales supporting it, and conclude that, on the whole, CCA is worth serious consideration when it comes to describing cognitive experiences. [less ▲]

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See detailFair Trade Milk Initiative in Belgium: Bricolage as an Empowering Strategy for Change
Feyereisen, Marlène ULg; Stassart, Pierre M ULg; Melard, François ULg

in Sociologia Ruralis (in press)

In a context of multiple crises, dairy farmers struggle to receive a fair remuneration for their work. This situation led to the creation of fair milk projects in Europe. But fair trade projects often ... [more ▼]

In a context of multiple crises, dairy farmers struggle to receive a fair remuneration for their work. This situation led to the creation of fair milk projects in Europe. But fair trade projects often suffer from ambiguous interpretations that place them simultaneously in and against the market. This study focuses on a Belgian milk label in order to analyse how dairy farmers developed a particular strategy to create their own fair milk. Based on semi-structured interviews and using the multi-level perspective, we propose that articulating the concepts of lock-ins, bricolage and ambiguity enables us to analyse the potential of this innovation for the transition of the Belgian dairy system. The study shows that fairness is often a matter of divergent interpretations, and its final actualisation is the product of emergent and negotiated relations. By using bricolage practices, the stakeholders reinforced their capacity to gain market power and act within the system they want to change. [less ▲]

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See detailSocial sustainability assessments in the biobased economy: Towards a systemic approach
Rafiaani, Parisa ULg; Kuppens, Tom; Van Dael, Miet et al

in Renewable & Sustainable Energy Reviews (in press)

The majority of impact assessments for the biobased economy are primarily focused on the environmental and (techno-)economic aspects, while social aspects are rarely considered. This study proposes a ... [more ▼]

The majority of impact assessments for the biobased economy are primarily focused on the environmental and (techno-)economic aspects, while social aspects are rarely considered. This study proposes a modified systemic approach for a social sustainability impact assessment of the biobased economy, based on a review on the common methodologies for assessing social impacts. Accordingly, the proposed approach follows the four general iterative steps of social life cycle analysis (SLCA) as it considers all life cycle phases of the biobased economy. The systemic approach considers the potential social impacts on local communities, workers, and consumers as the main three groups of the stakeholders. The review showed that the most common social indicators for inventory analysis within the biobased economy include health and safety, food security, income, employment, land- and worker-related concerns, energy security, profitability, and gender issues. Multi-criteria decision analysis (MCDA) was also highlighted as the broadly utilized methodology for aggregating the results of impact assessments within the biobased economy. Taking a life cycle perspective, this study provides a holistic view of the full sustainability of research, design, and innovation in the biobased economy by suggesting the integration of the social aspects with techno-economic and an environmental life cycle assessment. Our proposed systemic approach makes possible to integrate the social impacts that are highly valued by the affected stakeholders into the existing sustainability models that focus only on environmental and techno-economic aspects. We discuss the steps of the proposed systemic approach in order to identify the challenges of applying them within the biobased economy. These challenges refer mainly to the definition of the functional unit and system boundaries, the selection and the analysis of social indicators (inventory analysis), the aggregation of the inventory to impact categories, and the uncertainties associated with the social sustainability evaluation. The result of this review and the proposed systemic approach serve as a foundation for industry and policy makers to gain a better insight into the importance of social sustainability impacts assessment within the biobased economy. [less ▲]

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See detailEvaluation of different hydrocolloids to improve dough rheological properties and bread quality of potato-wheat flour
Liu, Xingli ULg; Mu, Taihua; Yamul, Karim Diego et al

in Journal of Industrial and Engineering Chemistry (in press)

The aim of study was to investigate the effect of hydroxylpropylmethylcellulose (HPMC), arabic gum (AG), konjac glucomannan (KG) and apple pectin (AP) at 2% (w/w, potato-wheat flour basis) on the potato ... [more ▼]

The aim of study was to investigate the effect of hydroxylpropylmethylcellulose (HPMC), arabic gum (AG), konjac glucomannan (KG) and apple pectin (AP) at 2% (w/w, potato-wheat flour basis) on the potato-wheat dough (the mass ratio was 1:1) rheological, fermentation properties and its bread quality. The tan δ of potato-wheat dough was significantly increased by adding HPMC compared to those of without adding hydrocolloids (from 0.337 to 0.425), which was close to wheat dough (0.531). Moreover, the dough height during fermentation process was significantly improved by adding hydrocolloids, with the order of HPMC (23.1mm) > AP (19.3mm) > AG (18.6mm) > KG (13.6mm). In addition, the potato-wheat protein bands of potato-wheat dough turned pale by adding hydrocolloids, suggesting higher molecular weight aggregation formed between proteins-hydrocolloids or proteins-proteins after fermentation process. Furthermore, HPMC significantly increased specific volume (from 1.45 to 2.22 ml/g), and hydrocolloids restrained the starch retrogradation of potato-wheat breads. [less ▲]

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See detailA review on early gut maturation and colonization in pigs, including biological and dietary factors affecting gut homeostasis
Everaert, Nadia ULg; Van Cruchten, Steven; Weström, Björn et al

in Animal Feed Science & Technology (in press)

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See detailChanges in biophysical membrane properties induced by the Budesonide/ Hydroxy-β-cyclodextrin complex
dos Santos, Andreia; Bayiha, Jules; Dufour, Gilles et al

in BBA Biomembranes (in press)

Budesonide (BUD), a poorly soluble anti-inflammatory drug, is used to treat patients suffering from asthma and COPD (Chronic Obstructive Pulmonary Disease). Hydroxypropyl-β-cyclodextrin (HPβCD), a ... [more ▼]

Budesonide (BUD), a poorly soluble anti-inflammatory drug, is used to treat patients suffering from asthma and COPD (Chronic Obstructive Pulmonary Disease). Hydroxypropyl-β-cyclodextrin (HPβCD), a biocompatible cyclodextrin known to interact with cholesterol, is used as a drug-solubilizing agent in pharmaceutical formulations. Budesonide administered as an inclusion complex within HPβCD (BUD:HPβCD) required a quarter of the nominal dose of the suspension formulation and significantly reduced neutrophil induced inflammation in a COPD mouse model exceeding the effect of each molecule administered individually. This suggests the role of lipid domains enriched in cholesterol for inflammatory signaling activation. In this context, we investigated the effect of BUD:HPβCD on the biophysical properties of membrane lipids. On cellular models (A549, lung epithelial cells), BUD:HPβCD extracted cholesterol similarly to HPβCD. On large unilamellar vesicles (LUVs), by using the fluorescent probes diphenylhexatriene (DPH) and calcein, we demonstrated an increase in membrane fluidity and permeability induced by BUD:HPβCD in vesicles containing cholesterol. On giant unilamellar vesicles (GUVs) and lipid monolayers, BUD:HPβCD induced the disruption of cholesterol-enriched raft-like liquid ordered domains as well as changes in lipid packing and lipid desorption from the cholesterol monolayers, respectively. Except for membrane fluidity, all these effects were enhanced when HPβCD was complexed with budesonide as compared with HPβCD. Since cholesterol-enriched domains have been linked to membrane signaling including pathways involved in inflammation processes, we hypothesized the effects of BUD:HPβCD could be partly mediated by changes in the biophysical properties of cholesterol-enriched domains. [less ▲]

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See detailNear-death experiences: actual considerations.
Charland-Verville, Vanessa ULg; Martial, Charlotte ULg; Cassol, Helena ULg et al

in Schnakers, Caroline; Laureys, Steven (Eds.) Coma and Disorders of Consciousness, Second Edition (in press)

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See detailAn active bacterial community linked to high chl-a concentrations in Antarctic winter-pack ice and evidence for the development of an anaerobic sea-ice bacterial community
Eronen-Rasimus, Eeva; Luhtanen, Anne-Mari; Rintala, Janne-Markus et al

in ISME Journal (The) (in press), 1-11

Antarctic sea-ice bacterial community composition and dynamics in various developmental stages were investigated during the austral winter in 2013. Thick snow cover likely insulated the ice, leading to ... [more ▼]

Antarctic sea-ice bacterial community composition and dynamics in various developmental stages were investigated during the austral winter in 2013. Thick snow cover likely insulated the ice, leading to high (o4 μg l–1) chlorophyll-a (chl-a) concentrations and consequent bacterial production. Typical sea-ice bacterial genera, for example, Octadecabacter, Polaribacter and Glaciecola, often abundant in spring and summer during the sea-ice algal bloom, predominated in the communities. The variability in bacterial community composition in the different ice types was mainly explained by the chl-a concentrations, suggesting that as in spring and summer sea ice, the sea-ice bacteria and algae may also be coupled during the Antarctic winter. Coupling between the bacterial community and sea-ice algae was further supported by significant correlations between bacterial abundance and production with chl-a. In addition, sulphate-reducing bacteria (for example, Desulforhopalus) together with odour of H2S were observed in thick, apparently anoxic ice, suggesting that the development of the anaerobic bacterial community may occur in sea ice under suitable conditions. In all, the results show that bacterial community in Antarctic sea ice can stay active throughout the winter period and thus possible future warming of sea ice and consequent increase in bacterial production may lead to changes in bacteria-mediated processes in the Antarctic sea-ice zone. [less ▲]

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See detailTo what extent is Immediate Constituency Analysis dependency-based? A survey of foundational texts
Mazziotta, Nicolas ULg; Kahane, Sylvain

in Proceedings of Depling 2017 (in press)

This paper investigates the seminal texts on Immediate Constituent Analysis and the associated diagrams. We show that the relations between the whole and its parts, that are typical of current phrase ... [more ▼]

This paper investigates the seminal texts on Immediate Constituent Analysis and the associated diagrams. We show that the relations between the whole and its parts, that are typical of current phrase structure trees, were less prominent in the early diagramming efforts than the relationships between units of the same level. This can be observed until the beginning of the 1960’s, including in Chomsky’s Syntactic Structures (1957). We discuss whether such analyses could be said “dependency-based”, according to an attempt to define this term. this term. [less ▲]

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See detailCritical review of surface-enhanced Raman spectroscopy applications in the pharmaceutical field
Cailletaud, Johan ULg; De Bleye, Charlotte ULg; Dumont, Elodie ULg et al

in Journal of Pharmaceutical & Biomedical Analysis (in press)

Surface-enhanced Raman spectroscopy (SERS) is a sensitive analytical tool used in the pharmaceutical field in recent years. SERS keeps all the advantages of classical Raman spectroscopy while being is ... [more ▼]

Surface-enhanced Raman spectroscopy (SERS) is a sensitive analytical tool used in the pharmaceutical field in recent years. SERS keeps all the advantages of classical Raman spectroscopy while being is more sensitive allowing its use for the detection and the quantification of low-dose substances contained in pharmaceutical samples. However, the analytical performance of SERS is limited due to the difficulty to implement a quantitative methodology correctly validated. Nevertheless, some studies reported the development of SERS quantitative methods especially in pharmaceutical approaches. In this context, this review presents the main concepts of the SERS technique. The different steps that need to be applied to develop a SERS quantitative method are also deeply described. The last part of the present manuscript gives a critical overview of the different SERS pharmaceutical applications that were developed for a non-exhaustive list of pharmaceutical compounds with the aim to highlights the validation criteria for each application. [less ▲]

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See detailThe social and political background of MPs of immigrant origin: are they any different?
Dodeigne, Jérémy ULg; Vintila, Daniela; Morales, Laura

in Morales, Laura; Saalfeld (Eds.) Pathways to Power: The Political Representation of Citizens of Immigrant Origin in Seven European Democracies (in press)

Detailed reference viewed: 15 (1 ULg)