Profil

Zervosen Astrid

Main Referenced Co-authors
Luxen, André  (31)
Joris, Bernard  (20)
Elling, Lothar (15)
Lemaire, Christian  (14)
Frère, Jean-Marie  (11)
Main Referenced Keywords
enzymatic synthesis (7); Indoleamine 2,3-dioxygenase (5); Tryptophan (5); nucleotide sugar (4); nucleotide sugars (4);
Main Referenced Unit & Research Centers
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège [BE] (24)
CIP - Centre d'Ingénierie des Protéines - ULiège [BE] (21)
Département de Chimie (1)
Main Referenced Disciplines
Biochemistry, biophysics & molecular biology (40)
Chemistry (27)
Microbiology (5)
Immunology & infectious disease (3)
Biotechnology (3)

Publications (total 58)

The most downloaded
684 downloads
Zervosen, A., Herman, R., Kerff, F., Herman, A., Bouillez, A., Prati, F., Pratt, R. F., Frère, J.-M., Joris, B., Luxen, A., Charlier, P., & Sauvage, E. (2011). Unexpected tricovalent binding mode of boronic acids within the active site of a penicillin binding protein. Journal of the American Chemical Society. doi:10.1021/ja200696y https://hdl.handle.net/2268/96177

The most cited

83 citations (OpenCitations)

Zervosen, A., Sauvage, E., Frère, J.-M., Charlier, P., & Luxen, A. (2012). Development of new drugs for an old target — the penicillin binding proteins. Molecules, 17 (11), 12478-505. doi:10.3390/molecules171112478 https://hdl.handle.net/2268/134239

Henrottin, J., Lemaire, C., Egrise, D., Zervosen, A., Van den Eynde, B., Plenevaux, A., Franci, X., Goldman, S., & Luxen, A. (June 2016). Fully automated radiosynthesis of N1-[18F]fluoroethyl-tryptophan and study of its biological activity as a new potential substrate for indoleamine 2,3-dioxygenase PET imaging. Nuclear Medicine and Biology, 43 (6), 379-389. doi:10.1016/j.nucmedbio.2016.03.001
Peer Reviewed verified by ORBi

Simon, J., Lamborelle, N., Zervosen, A., Lemaire, C., Joris, B., & Luxen, A. (2016). Development of solid-supported methodology for the preparation of peptidoglycan fragments containing (2S,6R)-diaminopimelic acid. Tetrahedron Letters. doi:10.1016/j.tetlet.2016.02.098
Peer Reviewed verified by ORBi

Henrottin, J., Lemaire, C., Zervosen, A., Egrise, D., Plenevaux, A., Doumont, G., Goldman, S., & Luxen, A. (May 2015). Fully automated radiosynthesis of 1-[18F]FETrp, a potential substrate for indoleamine 2,3-dioxygenase PET imaging [Poster presentation]. The 21st International Symposium on Radiopharmaceutical Sciences (ISRS 2015), University of Missouri, Columbia, Missouri, United States.

Henrottin, J., Lemaire, C., Zervosen, A., Egrise, D., Doumont, G., Plenevaux, A., Goldman, S., & Luxen, A. (02 April 2015). N1-(2-[18F]Fluoroethyl)-tryptophan: fully automated radiosynthesis, and study as potential substrate for indoleamine 2,3-dioxygenase PET imaging [Paper presentation]. La Journée-Rencontre des Jeunes Chimistes de la Société Royale de Chimie - 8ème édition, Namur, Belgium.

Henrottin, J., Zervosen, A., Lemaire, C., Sapunaric, F., Laurent, S., Van den Eynde, B., Goldman, S., Plenevaux, A., & Luxen, A. (January 2015). N1-Fluoroalkyltryptophan analogues: synthesis and in vitro study as potential substrates for indoleamine 2,3-dioxygenase. ACS Medicinal Chemistry Letters, 6, 260-265. doi:10.1021/ml500385d
Peer Reviewed verified by ORBi

Henrottin, J., Zervosen, A., Lemaire, C., Sapunaric, F., Laurent, S., Galleni, M., Van den Eynde, B., Goldman, S., Plenevaux, A., & Luxen, A. (June 2014). Synthesis of N-fluoroalkyl-tryptophan and study of their biological activity as potential substrates for indoleamine 2,3-dioxygenase [Poster presentation]. French-American Chemical society Symposium - FACS XV.

Denoël, T., Zervosen, A., Lemaire, C., Plenevaux, A., & Luxen, A. (2014). Synthesis of protected α-alkyl lanthionine derivatives. Tetrahedron, 70 (30), 4526 - 4533. doi:10.1016/j.tet.2014.05.004
Peer Reviewed verified by ORBi

Denoel, T., Zervosen, A., Lemaire, C., Joris, B., Herve, M., Blanot, D., Zaragoza, G., & Luxen, A. (2014). Enantioselective synthesis of [small alpha]-benzylated lanthionines and related tripeptides for biological incorporation into E. coli peptidoglycan. Organic and Biomolecular Chemistry. doi:10.1039/c4ob01476f
Peer Reviewed verified by ORBi

Denoel, T., Zervosen, A., Gerards, T., Lemaire, C., Joris, B., Blanot, D., & Luxen, A. (2014). Stereoselective synthesis of lanthionine derivatives in aqueous solution and their incorporation into the peptidoglycan of Escherichia coli. Bioorganic and Medicinal Chemistry, 22 (17), 4621-8. doi:10.1016/j.bmc.2014.07.023
Peer Reviewed verified by ORBi

Simon, J., Zervosen, A., Bouillez, A., & Luxen, A. (19 June 2013). Enantioselective synthesis of thioesters as substrates for high-through put screening assays of Penicillin Binding Proteins [Poster presentation]. Biomedica 2013, Aachen, Germany.

Henrottin, J., Zervosen, A., Lemaire, C., Galleni, M., & Luxen, A. (May 2013). Automated radiosynthesis of 1-(2-[18F]fluoroethyl)-tryptophan, a potential substrate for indoleamine 2,3-dioxygenase PET imaging [Poster presentation]. The 20th International Symposium on Radiopharmaceutical Sciences - ISRS 2013, Jéju, South Korea.

Gahungu, M., Arguelles Arias, A., Fickers, P., Zervosen, A., Joris, B., Damblon, C., & Luxen, A. (2013). Synthesis and biological evaluation of potential threonine synthase inhibitors: Rhizocticin A and Plumbemycin A. Bioorganic and Medicinal Chemistry, 21 (17), 4958-67. doi:10.1016/j.bmc.2013.06.064
Peer Reviewed verified by ORBi

Zervosen, A., Zapun, A., & Frère, J.-M. (January 2013). Inhibition of Streptococcus pneumoniae pencillin-binding protein 2x and Actinomadura R39 DD-peptidase activities by ceftaroline. Antimicrobial Agents and Chemotherapy, 57 (1), 661-663. doi:10.1128/AAC.01593-12
Peer Reviewed verified by ORBi

Zervosen, A., Sauvage, E., Bouillez, A., Herman, A., Amoroso, A. M., Joris, B., Charlier, P., & Luxen, A. (18 April 2012). Synthesis and evaluation of boronic acids as inhibitors of Penicillin Binding Proteins of classes A, B and C [Poster presentation]. Biomedica 2012, Liège, Belgium.

Zervosen, A., Sauvage, E., Frère, J.-M., Charlier, P., & Luxen, A. (2012). Development of new drugs for an old target — the penicillin binding proteins. Molecules, 17 (11), 12478-505. doi:10.3390/molecules171112478
Peer Reviewed verified by ORBi

Zervosen, A., Bouillez, A., Herman, A., Amoroso, A. M., Joris, B., Sauvage, E., Charlier, P., & Luxen, A. (2012). Synthesis and evaluation of boronic acids as inhibitors of Penicillin Binding Proteins of classes A, B and C. Bioorganic and Medicinal Chemistry, 20 (12), 3915-24. doi:10.1016/j.bmc.2012.04.018
Peer Reviewed verified by ORBi

Sliwa, A., Dive, G., Zervosen, A., Verlaine, O., Sauvage, E., & Marchand-Brynaert, J. (2012). Unprecedented inhibition of resistant penicillin binding proteins by bis-2-oxoazetidinyl macrocycles. MedChemComm, 3, 344-351. doi:10.1039/c2md00251e
Peer Reviewed verified by ORBi

Sosic, I., Turk, S., Sinreih, M., Trost, N., Verlaine, O., Amoroso, A. M., Zervosen, A., Luxen, A., Joris, B., & Gobec, S. (2012). Exploration of the chemical space of novel naphthalene-sulfonamide and anthranilic acid-based inhibitors of penicillin-binding Proteins. Acta Chimica Slovenica, 59 (2), 380-388.
Peer Reviewed verified by ORBi

Zervosen, A., Herman, R., Kerff, F., Herman, A., Bouillez, A., Prati, F., Pratt, R. F., Frère, J.-M., Joris, B., Luxen, A., Charlier, P., & Sauvage, E. (2011). Unexpected tricovalent binding mode of boronic acids within the active site of a penicillin binding protein. Journal of the American Chemical Society. doi:10.1021/ja200696y
Peer Reviewed verified by ORBi

Woon, E. C. Y., Zervosen, A., Sauvage, E., Simmons, K. J., Zivec, M., Inglis, S. R., Fishwick, C. W. G., Gobec, S., Charlier, P., Luxen, A., & Schofield, C. J. (2011). Structure Guided Development of Potent Reversibly Binding Penicillin Binding Protein Inhibitors. ACS Medicinal Chemistry Letters, 2 (3), 219-223. doi:10.1021/ml100260x
Peer Reviewed verified by ORBi

Turk, S., Verlaine, O., Gerards, T., Zivec, M., Humljan, J., Sosic, I., Amoroso, A. M., Zervosen, A., Luxen, A., Joris, B., & Gobec, S. (2011). New noncovalent inhibitors of penicillin-binding proteins from penicillin-resistant bacteria. PLoS ONE, 6 (5), 19418. doi:10.1371/journal.pone.0019418
Peer Reviewed verified by ORBi

Contreras-Martel, C., Amoroso, A. M., Woon, E. C. Y., Zervosen, A., Inglis, S., Martins, A., Verlaine, O., Rydzik, A. M., Job, V., Luxen, A., Joris, B., Schofield, C. J., & Dessen, A. (2011). Structure-Guided Design of Cell Wall Biosynthesis Inhibitors That Overcome beta-Lactam Resistance in Staphylococcus aureus (MRSA). ACS Chemical Biology. doi:10.1021/cb2001846
Peer Reviewed verified by ORBi

Derouaux, A., Turk, S., Olrichs, N. K., Gobec, S., Breukink, E., Amoroso, A. M., Offant, J., Bostock, J., Mariner, K., Chopra, I., Vernet, T., Zervosen, A., Joris, B., Frère, J.-M., Nguyen Van, M., & Terrak, M. (2011). Small molecule inhibitors of peptidoglycan synthesis targeting the lipid II precursor. Biochemical Pharmacology, 81 (9), 1098-105. doi:10.1016/j.bcp.2011.02.008
Peer Reviewed verified by ORBi

Mercier, F., Zervosen, A., Teller, N., Frère, J.-M., Herman, R., Pennartz, A., Joris, B., & Luxen, A. (2010). 1,6-AnhMurNAc derivatives for assay development of amidase AmiD. Bioorganic and Medicinal Chemistry, 18 (21), 7422-31. doi:10.1016/j.bmc.2010.09.010
Peer Reviewed verified by ORBi

Kerff, F., Petrella, S., Mercier, F., Sauvage, E., Herman, R., Pennartz, A., Zervosen, A., Luxen, A., Frère, J.-M., Joris, B., & Charlier, P. (2010). Specific Structural Features of the N-Acetylmuramoyl-l-Alanine Amidase AmiD from Escherichia coli and Mechanistic Implications for Enzymes of This Family. Journal of Molecular Biology, 397, 249-259. doi:10.1016/j.jmb.2009.12.038
Peer Reviewed verified by ORBi

Derouaux, A., Turk, S., Offant, J., Amoroso, A. M., Breukink, E., Bostock, J., Chopra, I., Zervosen, A., Joris, B., Nguyen Van, M., Vernet, T., Gobec, S., & Terrak, M. (November 2009). Identification and characterization of novel peptidoglycan glycosyltransferase inhibitors with antibacterial activity [Poster presentation]. Exploration and exploitation of bacterial cell wall biosynthesis, Warwick, United Kingdom.

Inglis, S. R., Zervosen, A., Woon, E. C. Y., Gerards, T., Teller, N., Fischer S, D., Luxen, A., & Schofield, C. J. (2009). Synthesis and Evaluation of 3-(Dihydroxyboryl)benzoic Acids as d,d-Carboxypeptidase R39 Inhibitors. Journal of Medicinal Chemistry. doi:10.1021/jm9009718
Peer Reviewed verified by ORBi

Zervosen, A., Frère, J.-M., & Zapun, A. (May 2009). Enzymatic Inhibition of Streptococcus pneumoniae PBP2x transpeptidase activity by ceftaroline [Poster presentation]. 19th ECCMID, Helsinki, Finland.

Miguet, L., Zervosen, A., Gerards, T., Pasha, F. P., Luxen, A., Nguyen-Distèche, M., & Thomas, A. (2009). Discovery of New Inhibitors of Resistant Streptococcus pneumoniae Penicillin Binding Protein (PBP) 2x by Structure-Based Virtual Screening. Journal of Medicinal Chemistry. doi:10.1021/jm900625q
Peer Reviewed verified by ORBi

Beck, J., Gharbi, S., Herteg-Fernea, A., Vercheval, L., Bebrone, C., Lassaux, P., Zervosen, A., & Marchand-Brynaert, J. (2009). Aminophosphonic Acids and Aminobis(phosphonic acids) as Potential Inhibitors of Penicillin-Binding Proteins. European Journal of Organic Chemistry, (1), 85-97. doi:10.1002/ejoc.200800812
Peer Reviewed verified by ORBi

Duez, C., Zervosen, A., Teller, N., Melkonian, R., Banzubazé, E., Bouillenne, F., Luxen, A., & Frère, J.-M. (2009). Characterization of the proteins encoded by the Bacillus subtilis yoxA-dacC operon. FEMS Microbiology Letters, 300, 42-47. doi:10.1111/j.1574-6968.2009.01761.x
Peer Reviewed verified by ORBi

Sauvage, E., Zervosen, A., Dive, G., Herman, R., Amoroso, A. M., Joris, B., Fonzé, E., Pratt, R., Luxen, A., Charlier, P., & Kerff, F. (2009). Structural basis of the inhibition of class A beta-lactamases and penicillin-binding proteins by 6-beta-iodopenicillanate. Journal of the American Chemical Society, 131 (42), 15262-15269. doi:10.1021/ja9051526
Peer Reviewed verified by ORBi

Zervosen, A., Saegerman, C., Antoniotti, I., Robert, B., Ruth, N., Collard, A., Schynts, F., Galleni, M., & Mercuri, P. (2008). Characterization of the cattle serum antibody responses against TEM beta-lactamase and the nonimmunogenic Escherichia coli heat-stable enterotoxin (STaI). FEMS Immunology and Medical Microbiology, 54 (3), 319-329. doi:10.1111/j.1574-695X.2008.00482.x
Peer Reviewed verified by ORBi

Macheboeuf, P., Fischer, D. S., Brown, T. J., Zervosen, A., Luxen, A., Joris, B., Dessen, A., & Schofield, C. J. (September 2007). Structural and mechanistic basis of penicillin-binding protein inhibition by lactivicins. Nature Chemical Biology, 3 (9), 565-569. doi:10.1038/nchembio.2007.21
Peer Reviewed verified by ORBi

Mercier, F., Zervosen, A., Lemaire, C., Plenevaux, A., Joris, B., & Luxen, A. (22 March 2007). Synthesis of anhydro-muramic acid derivatives as substrates for MurNAc amidase [Poster presentation]. Biomedica, Aachen, Germany.

Mercier, F., Lemaire, C., Plenevaux, A., Nguyen-Distèche, M., Zervosen, A., Joris, B., & Luxen, A. (17 May 2006). Synthesis of anhydro-muramic acid derivatives as substrates for MurNAc amidase [Poster presentation]. Bioforum 2006.

Fraipont, C., Sapunaric, F., Zervosen, A., Auger, G., Devreese, B., Lioux, T., Blanot, D., Mengin-Lecreulx, D., Herdewijn, P., Van Beeumen, J., Frère, J.-M., & Nguyen-Distèche, M. (28 March 2006). Glycosyl transferase activity of the Escherichia coli penicillin-binding protein 1b: Specificity profile for the substrate. Biochemistry, 45 (12), 4007-4013. doi:10.1021/bi051055m
Peer Reviewed verified by ORBi

Mercier, F., Lemaire, C., Plenevaux, A., Nguyen, M., Zervosen, A., Joris, B., & Luxen, A. (10 October 2005). Synthesis of anhydro-muranic acid derivatives as substrates for MurNAc amidase [Poster presentation]. 9. International SFB-Symposium. Asymmetric Synthesis with Chemical and Biological Methods, Aachen, Germany.

Teller, N., Lemaire, C., Plenevaux, A., Nguyen, M., Zervosen, A., Joris, B., & Luxen, A. (10 October 2005). Synthesis of protected meso-diaminopimelic acid [Poster presentation]. 9. International SFB-Symposium. Asymmetric Synthesis with Chemical and Biological Methods, Aachen, Germany.

Zervosen, A., Lu, W.-P., Chen, Z., White, R. E., Demuth, T. P., & Frère, J.-M. (March 2004). Interactions between penicillin-binding proteins (PBPs) and two novel classes of PBP inhibitors, arylalkylidene rhodanines and arylalkylidene iminothiazolidin-4-ones. Antimicrobial Agents and Chemotherapy, 48 (3), 961-969. doi:10.1128/AAC.48.3.961-969.2004
Peer Reviewed verified by ORBi

Zervosen, A., Elling, L., Nieder, V., Kamerling, J. P., Vliegenthart, J. F., & Gutierrez Gallego, R. (08 October 2003). Nucleotidaktivierte Di- und Oligosaccharide sowie Verfahren zu deren Herstellung.

Zervosen, A., Valladares, M. H., Devreese, B., Prosperi, C., Adolph, H.-W., Mercuri, P., Vanhove, M., Amicosante, G., van Beeumen, J., Frère, J.-M., & Galleni, M. (July 2001). Inactivation of Aeromonas Hydrophila Metallo-Beta-Lactamase by Cephamycins and Moxalactam. European Journal of Biochemistry, 268 (13), 3840-50. doi:10.1046/j.1432-1327.2001.02298.x
Peer Reviewed verified by ORBi

Zervosen, A., Nieder, V., Gallego, R. G., Kamerling, J. P., Vliegenthart, J. F. G., & Elling, L. (February 2001). Synthesis of nucleotide-activated oligosaccharides by beta-galactosidase from Bacillus circulans. Biological Chemistry, 382 (2), 299-311. doi:10.1515/BC.2001.037
Peer Reviewed verified by ORBi

Zervosen, A., Elling, L., Nieder, V., Kamerling, J. P., Vliegenthart, J. F., & Gutierrez Gallego, R. (17 January 2001). Nucleotidaktivierte Di- und Oligosaccharide sowie Verfahren zu deren Herstellung.

Hoersch, B., Seiffert-Stoeriko, A., Marquardt, R., Zervosen, A., Elling, L., & Kula, M.-R. (05 October 1999). Method for the enzymatic galactosylation of monosaccharides and oligosaccharides.

Marquardt, R., Hoersch, B., Seiffert-Stoeriko, A., Stein, A., Zervosen, A., Elling, L., Kula, M.-R., Verseck, S., Distler, J., & Piepersberg, W. (02 February 1999). Process for the synthesis of nucleotide-6-deoxy-D-xylo-4-hexulosen.

Zervosen, A., & Elling, L. (1999). Application of sucrose synthase in the synthesis of nucleotide sugars and saccharides. In C. Bucke (Ed.), Carbohydrate Biotechnology Protocols (pp. 235-254). Totowa, United States: Humana Press.

Elling, L., Zervosen, A., Gallego, R. G., Nieder, V., Malissard, M., Berger, E. G., Vliegenthart, J. F. G., & Kamerling, J. P. (1999). UDP-N-Acetyl-alpha-D-glucosamine as acceptor substrate of beta-1,4-galactosyltransferase. Enzymatic synthesis of UDP-N-acetyllactosamine. Glycoconjugate Journal, 16 (7), 327-36. doi:10.1023/A:1007039825505
Peer Reviewed verified by ORBi

Zervosen, A., Romer, U., & Elling, L. (1998). Application of recombinant sucrose synthase large scale synthesis of ADP-glucose. Journal of Molecular Catalysis B: Enzymatic, 5 (1-4), 25-28. doi:10.1016/S1381-1177(98)00040-X
Peer Reviewed verified by ORBi

Zervosen, A., & Elling, L. (22 September 1997). Large scale enzymatic synthesis of ADP-glucose [Poster presentation]. Biotrans'97, 3rd International Symposium on Biocatalysis and Biotransformations, La Grande Motte, France.

Zervosen, A., Stein, A., Adrian, H., & Elling, L. (1996). Combined enzymatic synthesis of nucleotide (deoxy) sugars from sucrose and nucleoside monophosphates. Tetrahedron, 52 (7), 2395-2404. doi:10.1016/0040-4020(95)01081-5
Peer Reviewed verified by ORBi

Zervosen, A., & Elling, L. (1996). A novel three-enzyme reaction cycle for the synthesis of N-acetyllactosamine with in situ regeneration of uridine 5'-diphosphate glucose and uridine 5'-diphosphate galactose. Journal of the American Chemical Society, 118 (8), 1836-1840. doi:10.1021/ja953495e
Peer Reviewed verified by ORBi

Hokke, C. H., Zervosen, A., Elling, L., Joziasse, D. H., & van den Eijnden, D. H. (1996). One-pot enzymatic synthesis of the Gal alpha 1-->3Gal beta 1-->4GlcNAc sequence with in situ UDP-Gal regeneration. Glycoconjugate Journal, 13 (4), 687-92. doi:10.1007/BF00731458
Peer Reviewed verified by ORBi

Zervosen, A., Stein, A., & Elling, L. (July 1995). Preparative enzymatic synthesis and in situ regeneration of nucleotide sugars with sucrose synthase [Paper presentation]. Eurocarb VIII, 8th European Carbohydrate Symposium, Sevilla, Spain.

Zervosen, A., & Elling, L. (30 May 1995). Praeparative enzymatische Synthese von Nucleotidzuckern mit Saccharose Synthase aus Reis [Poster presentation]. DECHEMA 1995, Wiesbaden, Germany.

Elling, L., Grothus, M., Zervosen, A., & Kula, M.-R. (1995). Application of sucrose synthase from rice grains for the synthesis of carbohydrates. Annals of the New York Academy of Sciences, 750, 329-31. doi:10.1111/j.1749-6632.1995.tb19975.x
Peer Reviewed verified by ORBi

ELLING, L., GULDENBERG, B., GROTHUS, M., Zervosen, A., PEUS, M., HELFER, A., STEIN, A., ADRIAN, H., & KULA, M.-R. (1995). ISOLATION OF SUCROSE SYNTHASE FROM RICE (ORYZA-SATIVA) GRAINS IN PILOT-SCALE FOR APPLICATION IN CARBOHYDRATE SYNTHESIS. Biotechnology and Applied Biochemistry, 21 (Part 1), 29-37.
Peer Reviewed verified by ORBi

Zervosen, A., ELLING, L., & KULA, M.-R. (1994). CONTINUOUS ENZYMATIC-SYNTHESIS OF 2'-DEOXYTHYMIDINE-5'(ALPHA-D-GLUCOPYRANOSYL)DIPHOSPHATE. Angewandte Chemie International Edition, 33 (5), 571-572. doi:10.1002/anie.199405711
Peer Reviewed verified by ORBi

Contact ORBi