Article (Scientific journals)
The Yin and Yang of cell cycle progression and differentiation in the oligodendroglial lineage
Nguyen, Laurent; Borgs, Laurence; Vandenbosch, Renaud et al.
2006In Mental Retardation and Developmental Disabilities Research Reviews, 12 (2), p. 85-96
Peer Reviewed verified by ORBi
 

Files


Full Text
MRDD (2006) Nguyen.pdf
Publisher postprint (316.99 kB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
oligodendrocyte; OPC; glia; myelin; neural stem cell; OLIG; Cdk2; p27
Abstract :
[en] In white matter disorders such as leukodystrophies (LD), periventricular leucomalacia (PVL), or multiple sclerosis (MS), the hypomyelination or the remyelination failure by oligodendrocyte progenitor cells involves errors in the sequence of events that normally occur during development when progenitors proliferate, migrate through the white matter, contact the axon, and differentiate into myelin-forming oligodendrocytes. Multiple mechanisms underlie the eventual progressive deterioration that typifies the natural history of developmental demyelination in LID and PVL and of adult-onset demyelination in MS. Over the past few years, pathophysiological studies have mostly focused on seeking abnormalities that impede oligodendroglial maturation at the level of migration, myelination, and survival. In contrast, there has been a strikingly lower interest for early proliferative and differentiation events that are likely to be equally critical for white matter development and myelin repair. This review highlights the Yin and Yang principles of interactions between intrinsic factors that coordinately regulate progenitor cell division and the onset of differentiation, i.e. the initial steps of oligodendrocyte lineage progression that are obviously crucial in health and diseases. (C) 2006 Wiley-Liss, Inc.
Disciplines :
Biochemistry, biophysics & molecular biology
Anatomy (cytology, histology, embryology...) & physiology
Author, co-author :
Nguyen, Laurent  ;  Université de Liège - ULiège > Département des sciences cliniques > Neurologie
Borgs, Laurence ;  Université de Liège - ULiège > CNCM/ Centre fac. de rech. en neurobiologie cell. et moléc.
Vandenbosch, Renaud  ;  Université de Liège - ULiège > CNCM/ Centre fac. de rech. en neurobiologie cell. et moléc.
Mangin, Jean-Marie;  Université de Liège - ULiège
Beukelaers, Pierre ;  Université de Liège - ULiège > CNCM/ Centre fac. de rech. en neurobiologie cell. et moléc.
Moonen, Gustave  ;  Université de Liège - ULiège > Département des sciences cliniques > Neurologie - Doyen de la Faculté de Médecine
Gallo, Vittorio;  Children Hospital
Malgrange, Brigitte  ;  Université de Liège - ULiège > CNCM/ Centre fac. de rech. en neurobiologie cell. et moléc.
Belachew, Shibeshih ;  Université de Liège - ULiège > Département des sciences cliniques > Neurologie
Language :
English
Title :
The Yin and Yang of cell cycle progression and differentiation in the oligodendroglial lineage
Publication date :
2006
Journal title :
Mental Retardation and Developmental Disabilities Research Reviews
ISSN :
1080-4013
eISSN :
1098-2779
Publisher :
Wiley Liss, Inc., Hoboken, United States - New Jersey
Volume :
12
Issue :
2
Pages :
85-96
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 27 January 2009

Statistics


Number of views
92 (5 by ULiège)
Number of downloads
3 (3 by ULiège)

Scopus citations®
 
22
Scopus citations®
without self-citations
22
OpenCitations
 
20

Bibliography


Similar publications



Contact ORBi