Article (Scientific journals)
Chemical Constituents of the Leaves of Caloncoba welwitschii Gilg.
Douanla, Pascal D.; Tchuendem, Marguerite Hortence K.; Tchinda, Alembert T. et al.
2018In Phytochemistry Letters, 23 (October 2017), p. 5-8
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Keywords :
Antiplasmodial activities; Caloncoba welwitschii; Flacourtiaceae; Flavonol glucosides; Friedelanes
Abstract :
[en] Two new compounds namely acetylcaloncobaside (1) and friedocaloncobic acid (2) were isolated from the leaves of Caloncoba welwitschii together with six known compounds. Their structures were determined by standard spectroscopic methods including one- and two-dimensional NMR, EI-MS, and HRESIMS. The new compounds were established as kaempferol 4′,7-dimethoxy-3-O-(3″,4″,6″-O-triacetyl)-β-null-glucopyranoside (1) and 15β-hydroxy-3-oxo-28-friedelanoic acid (2). The isolated compounds were evaluated for their ability to inhibit the 3D7 strain of Plasmodium falciparum, using the semi-automated in vitro model with parasite lactate dehydrogenase assay.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Douanla, Pascal D.
Tchuendem, Marguerite Hortence K.
Tchinda, Alembert T.
Kuiate, Turibio
Zofou, Denis
Cieckiewicz, Ewa ;  Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Frederich, Michel  ;  Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Nkengfack, Augustin E.
Language :
English
Title :
Chemical Constituents of the Leaves of Caloncoba welwitschii Gilg.
Publication date :
2018
Journal title :
Phytochemistry Letters
ISSN :
1874-3900
eISSN :
1876-7486
Publisher :
Elsevier
Volume :
23
Issue :
October 2017
Pages :
5-8
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 31 December 2017

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