Article (Scientific journals)
Effect of AP102, a subtype 2 and 5 specific somatostatin analog, on glucose metabolism in rats
Tarasco, Erika; Seebeck, Petra; Pfundstein, Svende et al.
2017In Endocrine
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Abstract :
[en] Somatostatin analogs are widely used to treat conditions associated with hormonal hypersecretion such as acromegaly and metastatic neuroendocrine tumors. First generation somatostatin analogs, such as octreotide and lanreotide, have high affinity for somatostatin receptor subtype 2 (SSTR2), but have incomplete efficacy in many patients. Pasireotide targets multiple SSTRs, having the highest affinity for SSTR5, but causes hyperglycemia and diabetes mellitus in preclinical and clinical studies. AP102 is a new somatostatin analogs with high affinity at both SSTR2 and SSTR5. We aimed to characterize the effects of AP102 vs. pasireotide on random and dynamic glucose levels, glucoregulatory hormone concentrations and growth axis measures in healthy Sprague-Dawley rats.
Disciplines :
Endocrinology, metabolism & nutrition
Author, co-author :
Tarasco, Erika
Seebeck, Petra
Pfundstein, Svende
Daly, Adrian  ;  Université de Liège > Département des sciences cliniques > Endocrinologie
Eugster, Philippe J.
Harris, Alan G.
Grouzmann, Eric
Lutz, Thomas A.
Boyle, Christina N.
Language :
English
Title :
Effect of AP102, a subtype 2 and 5 specific somatostatin analog, on glucose metabolism in rats
Publication date :
18 August 2017
Journal title :
Endocrine
ISSN :
1355-008X
eISSN :
1559-0100
Publisher :
Humana Press, Totowa, United States - New Jersey
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 18 August 2017

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