Article (Scientific journals)
OLFM4, KNG1 and Sec24C identified by proteomics and immunohistochemistry as potential markers of early colorectal cancer stages
QUESADA-CALVO, Florence; MASSOT, Charlotte; Bertrand, Virginie et al.
2017In Clinical Proteomics, 24 (9)
Peer Reviewed verified by ORBi
 

Files


Full Text
OLFM4, KNG1 and Sec24C identified by proteomics and immunohistochemistry as potential markers of early colorectal cancer stages.pdf
Publisher postprint (1.87 MB)
open acces
Download

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Proteomics; colorectal cancer; biomarkers
Abstract :
[en] Abstract Background: Despite recent advances in colorectal cancer (CRC) diagnosis and population screening programs, the identification of patients with preneoplastic lesions or with early CRC stages remains challenging and is important for reducing CRC incidence and increasing patient’s survival. Methods: We analysed 76 colorectal tissue samples originated from early CRC stages, normal or inflamed mucosa by label-free proteomics. The characterisation of three selected biomarker candidates was performed by immunohisto‑ chemistry on an independent set of precancerous and cancerous lesions harbouring increasing CRC stages. Results: Out of 5258 proteins identified, we obtained 561 proteins with a significant differential distribution among groups of patients and controls. KNG1, OLFM4 and Sec24C distributions were validated in tissues and showed differ‑ ent expression levels especially in the two early CRC stages compared to normal and preneoplastic tissues. Conclusion: We highlighted three proteins that require further investigations to better characterise their role in early CRC carcinogenesis and their potential as early CRC markers.
Research center :
GIGA-I3 - Giga-Infection, Immunity and Inflammation - ULiège
Disciplines :
Gastroenterology & hepatology
Author, co-author :
QUESADA-CALVO, Florence ;  Université de Liège > GIGA-R > Translationnal gastroenterology
MASSOT, Charlotte ;  Centre Hospitalier Universitaire de Liège - CHU > GIGA-R > Hépato-gastroentérologie et oncologie digestive -gastroentérologie translationnelle
Bertrand, Virginie ;  Université de Liège > Département de chimie (sciences) > Département de chimie (sciences)
Longuespée, Rémi ;  Université de Liège > Département de chimie (sciences) > Center for Analytical Research and Technology (CART)
BLETARD, Noëlla ;  Centre Hospitalier Universitaire de Liège - CHU > Service d'anatomie et cytologie pathologiques
SOMJA, Joan ;  Centre Hospitalier Universitaire de Liège - CHU > Service dermatopathologie
Mazzucchelli, Gabriel  ;  Université de Liège > Département de chimie (sciences) > Laboratoire de spectrométrie de masse (L.S.M.)
Smargiasso, Nicolas ;  Université de Liège > Département de chimie (sciences) > Laboratoire de spectrométrie de masse (L.S.M.)
Baiwir, Dominique  ;  Université de Liège > GIGA-Technology platforms : Plate-forme protéomique
De Pauw-Gillet, Marie-Claire ;  Université de Liège > Département des sciences biomédicales et précliniques > Histologie - Cytologie
Delvenne, Philippe ;  Université de Liège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
MALAISE, Michel ;  Centre Hospitalier Universitaire de Liège - CHU > Service de rhumatologie
COIMBRA MARQUES, Carla ;  Centre Hospitalier Universitaire de Liège - CHU > Chirurgie abdo, sénologique, endocrine et de transplantation
POLUS, Marc ;  Centre Hospitalier Universitaire de Liège - CHU > Service de gastroentérologie, hépatologie, onco. digestive
De Pauw, Edwin  ;  Université de Liège > Département de chimie (sciences) > Laboratoire de spectrométrie de masse (L.S.M.)
MEUWIS, Marie-Alice  ;  Centre Hospitalier Universitaire de Liège - CHU > GIGA-R > Service d'hépato-gastroentérologie et oncologie digestive/ Gastroenterologie Translationnelle
Louis, Edouard  ;  Université de Liège > Département des sciences cliniques > Hépato-gastroentérologie
More authors (7 more) Less
Language :
English
Title :
OLFM4, KNG1 and Sec24C identified by proteomics and immunohistochemistry as potential markers of early colorectal cancer stages
Publication date :
24 March 2017
Journal title :
Clinical Proteomics
ISSN :
1542-6416
eISSN :
1559-0275
Publisher :
Springer Science & Business Media B.V.
Volume :
24
Issue :
9
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
plan cancer, Télévie-FRNS, CAC, SRBG
Available on ORBi :
since 31 May 2017

Statistics


Number of views
141 (35 by ULiège)
Number of downloads
146 (19 by ULiège)

Scopus citations®
 
42
Scopus citations®
without self-citations
39
OpenCitations
 
38

Bibliography


Similar publications



Contact ORBi