Article (Scientific journals)
Host DNA released by NETosis promotes rhinovirus-induced type-2 allergic asthma exacerbation.
Toussaint, Marie; Jackson, David J.; Swieboda, Dawid et al.
2017In Nature Medicine, 23, p. 681-691
Peer Reviewed verified by ORBi
 

Files


Full Text
2017_NatMed_NETs_Main.pdf
Publisher postprint (1.43 MB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Abstract :
[en] Respiratory viral infections represent the most common cause of allergic asthma exacerbations. Amplification of the type-2 immune response is strongly implicated in asthma exacerbation, but how virus infection boosts type-2 responses is poorly understood. We report a significant correlation between the release of host double-stranded DNA (dsDNA) following rhinovirus infection and the exacerbation of type-2 allergic inflammation in humans. In a mouse model of allergic airway hypersensitivity, we show that rhinovirus infection triggers dsDNA release associated with the formation of neutrophil extracellular traps (NETs), known as NETosis. We further demonstrate that inhibiting NETosis by blocking neutrophil elastase or by degrading NETs with DNase protects mice from type-2 immunopathology. Furthermore, the injection of mouse genomic DNA alone is sufficient to recapitulate many features of rhinovirus-induced type-2 immune responses and asthma pathology. Thus, NETosis and its associated extracellular dsDNA contribute to the pathogenesis and may represent potential therapeutic targets of rhinovirus-induced asthma exacerbations.
Disciplines :
Life sciences: Multidisciplinary, general & others
Author, co-author :
Toussaint, Marie;  Imperial College London, London, UK
Jackson, David J.;  Imperial College London, London, UK
Swieboda, Dawid;  Imperial College London, London, UK
Guedan, Anabel;  Imperial College London, London, UK
Tsourouktsoglou, Theodora-Dorita;  The Francis Crick Institute, UK
Ching, Yee Man;  Imperial College London, London, UK
Radermecker, Coraline ;  Université de Liège > Département des sciences fonctionnelles (DSF) > GIGA-R : Biochimie et biologie moléculaire
Makrinioti, Heidi;  Imperial College London, London, UK
Aniscenko, Julia;  Imperial College London, London, UK
Edwards, Michael R.;  Imperial College London, London, UK
Solari, Roberto;  Imperial College London, London, UK
Farnir, Frédéric  ;  Université de Liège > Département des productions animales (DPA) > Biostatistiques et bioinformatique appliquées aux sc. vétér.
Papayannopoulos, Venizelos;  The Frank Crick Institute
Bureau, Fabrice  ;  Université de Liège > Département des sciences fonctionnelles (DSF) > GIGA-R : Biochimie et biologie moléculaire
Marichal, Thomas   ;  Université de Liège > Département des sciences fonctionnelles (DSF) > GIGA-R : Biochimie et biologie moléculaire
Johnston, Sebastian Lennox ;  Imperial College London, London, UK
More authors (6 more) Less
 These authors have contributed equally to this work.
Language :
English
Title :
Host DNA released by NETosis promotes rhinovirus-induced type-2 allergic asthma exacerbation.
Publication date :
2017
Journal title :
Nature Medicine
ISSN :
1078-8956
eISSN :
1546-170X
Publisher :
Nature Publishing Group, United Kingdom
Volume :
23
Pages :
681-691
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 19 May 2017

Statistics


Number of views
122 (31 by ULiège)
Number of downloads
15 (15 by ULiège)

Scopus citations®
 
229
Scopus citations®
without self-citations
213
OpenCitations
 
209

Bibliography


Similar publications



Contact ORBi