Koletzko, B., Goulet, O., Hunt, J., Krohn, K., Shamir, R., Guidelines on Paediatric Parenteral Nutrition of the European Society of Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) and the European Society for Clinical Nutrition and Metabolism (ESPEN), supported by the European Society of Paediatric Research (ESPR). J Pediatr Gastroenterol Nutr 41:Suppl. 2 (2005), S1–S87.
Krohn, K., Koletzko, B., Parenteral lipid emulsions in paediatrics. Curr Opin Clin Nutr Metab Care 9 (2006), 319–323.
Lapillonne, A., Enteral and parenteral lipid requirements of preterm infants. World Rev Nutr Diet 110 (2014), 82–98.
Carpentier, Y.A., Deckelbaum, R.J., In vivo handling and metabolism of lipid emulsions. World Rev Nutr Diet 112 (2015), 57–62.
Vlaardingerbroek, H., van Goudoever, J.B., Intravenous lipids in preterm infants: impact on laboratory and clinical outcomes and long-term consequences. World Rev Nutr Diet 112 (2015), 71–80.
Wanten, G., Beunk, J., Naber, A., Swinkels, D., Tocopherol isoforms in parenteral lipid emulsions and neutrophil activation. Clin Nutr 21 (2002), 417–422.
Webb, A.N., Hardy, P., Peterkin, M., Lee, O., Shalley, H., Croft, K.D., et al. Tolerability and safety of olive oil-based lipid emulsion in critically ill neonates: a blinded randomized trial. Nutrition 24 (2008), 1057–1064.
Tomsits, E., Pataki, M., Tolgyesi, A., Fekete, G., Rischak, K., Szollar, L., Safety and efficacy of a lipid emulsion containing a mixture of soybean oil, medium-chain triglycerides, olive oil, and fish oil: a randomised, double-blind clinical trial in premature infants requiring parenteral nutrition. J Pediatr Gastroenterol Nutr 51 (2010), 514–521.
Lapillonne, A., Groh-Wargo, S., Gonzalez, C.H., Uauy, R., Lipid needs of preterm infants: updated recommendations. J Pediatr 162 (2013), S37–S47.
Koletzko, B., Boey, C.C.M., Campoy, C., Carlson, S.E., Chang, N., Guillermo-Tuazon, M.A., et al. Current information and Asian perspectives on long-chain polyunsaturated fatty acids in pregnancy, lactation and infancy. Systematic review and practice recommendations from an Early Nutrition Academy workshop. Ann Nutr Metab 65 (2014), i49–i80.
Vlaardingerbroek, H., Vermeulen, M.J., Rook, D., van den Akker, C.H., Dorst, K., Wattimena, J.L., et al. Safety and efficacy of early parenteral lipid and high-dose amino acid administration to very low birth weight infants. J Pediatr 163 (2013), 638–644 e1-5.
Simmer, K., Rao, S.C., Early introduction of lipids to parenterally-fed preterm infants. Cochrane Database Syst Rev, 2005, CD005256.
Vlaardingerbroek, H., Veldhorst, M.A., Spronk, S., van den Akker, C.H., van Goudoever, J.B., Parenteral lipid administration to very-low-birth-weight infants–early introduction of lipids and use of new lipid emulsions: a systematic review and meta-analysis. Am J Clin Nutr 96 (2012), 255–268.
Moyses, H.E., Johnson, M.J., Leaf, A.A., Cornelius, V.R., Early parenteral nutrition and growth outcomes in preterm infants: a systematic review and meta-analysis. Am J Clin Nutr 97 (2013), 816–826.
Fischer, C.J., Maucort-Boulch, D., Essomo Megnier-Mbo, C.M., Remontet, L., Claris, O., Early parenteral lipids and growth velocity in extremely-low-birth-weight infants. Clin Nutr 33 (2014), 502–508.
Drenckpohl, D., McConnell, C., Gaffney, S., Niehaus, M., Macwan, K.S., Randomized trial of very low birth weight infants receiving higher rates of infusion of intravenous fat emulsions during the first week of life. Pediatrics 122 (2008), 743–751.
dit Trolli, S.E., Kermorvant-Duchemin, E., Huon, C., Bremond-Gignac, D., Lapillonne, A., Early lipid supply and neurological development at one year in very low birth weight (VLBW) preterm infants. Early Hum Dev 88:Suppl. 1 (2012), S25–S29.
Ibrahim, H.M., Jeroudi, M.A., Baier, R.J., Dhanireddy, R., Krouskop, R.W., Aggressive early total parental nutrition in low-birth-weight infants. J Perinatol 24 (2004), 482–486.
Vlaardingerbroek, H., Schierbeek, H., Rook, D., Vermeulen, M.J., Dorst, K., Vermes, A., et al. Albumin synthesis in very low birth weight infants is enhanced by early parenteral lipid and high-dose amino acid administration. Clin Nutr 35 (2016), 344–350.
Roelants, J.A., Vlaardingerbroek, H., van den Akker, C.H., de Jonge, R.C., van Goudoever, J.B., Vermeulen, M.J., Two-year follow-up of a randomized controlled nutrition intervention trial in very low-birth-weight infants. J Parenter Enteral Nutr, 2016 148607116678196 [Epub ahead of print].
Amin, S.B., Effect of free fatty acids on bilirubin-albumin binding affinity and unbound bilirubin in premature infants. J Parenter Enteral Nutr 34 (2010), 414–420.
Gregory, K., Update on nutrition for preterm and full-term infants. J Obstet Gynecol Neonatal Nurs 34 (2005), 98–108.
Lewandowski, A.J., Lazdam, M., Davis, E., Kylintireas, I., Diesch, J., Francis, J., et al. Short-term exposure to exogenous lipids in premature infants and long-term changes in aortic and cardiac function. Arterioscler Thromb Vasc Biol 31 (2011), 2125–2135.
Shoji, H., Hisata, K., Suzuki, M., Yoshikawa, N., Suganuma, H., Ohkawa, N., et al. Effects of parenteral soybean oil lipid emulsion on the long-chain polyunsaturated fatty acid profile in very-low-birth-weight infants. Acta Paediatr 100 (2011), 972–976.
Lehner, F., Demmelmair, H., Roschinger, W., Decsi, T., Szasz, M., Adamovich, K., et al. Metabolic effects of intravenous LCT or MCT/LCT lipid emulsions in preterm infants. J Lipid Res 47 (2006), 404–411.
Deshpande, G.C., Simmer, K., Mori, T., Croft, K., Parenteral lipid emulsions based on olive oil compared with soybean oil in preterm (<28 weeks' gestation) neonates: a randomised controlled trial. J Pediatr Gastroenterol Nutr 49 (2009), 619–625.
Waitzberg, D.L., Torrinhas, R.S., The complexity of prescribing intravenous lipid emulsions. World Rev Nutr Diet 112 (2015), 150–162.
Lapillonne, A., Eleni dit Trolli, S., Kermorvant-Duchemin, E., Postnatal docosahexaenoic acid deficiency is an inevitable consequence of current recommendations and practice in preterm infants. Neonatology 98 (2010), 397–403.
Zhao, Y., Wu, Y., Pei, J., Chen, Z., Wang, Q., Xiang, B., Safety and efficacy of parenteral fish oil-containing lipid emulsions in premature neonates: a meta-analysis of randomized controlled trials. J Pediatr Gastroenterol Nutr 60 (2015), 708–716.
D'Ascenzo, R., D'Egidio, S., Angelini, L., Bellagamba, M.P., Manna, M., Pompilio, A., et al. Parenteral nutrition of preterm infants with a lipid emulsion containing 10% fish oil: effect on plasma lipids and long-chain polyunsaturated fatty acids. J Pediatr 159 (2011), 33–38 e1.
Lapillonne, A., Carlson, S.E., Polyunsaturated fatty acids and infant growth. Lipids 36 (2001), 901–911.
Gawecka, A., Michalkiewicz, J., Kornacka, M.K., Luckiewicz, B., Kubiszewska, I., Immunologic properties differ in preterm infants fed olive oil vs soy-based lipid emulsions during parenteral nutrition. J Parenter Enteral Nutr 32 (2008), 448–453.
Li, X., Ying, J., Zeng, S., Li, Y., Yang, H., Shen, L., et al. The effects of a short-term long-chain-triglyceride infusion on the postoperative immune function of pediatric patients receiving a gastrointestinal surgical procedure. J Parenter Enteral Nutr 32 (2008), 72–77.
Pontes-Arruda, A., Liu, F.X., Turpin, R.S., Mercaldi, C.J., Hise, M., Zaloga, G., Bloodstream infections in patients receiving manufactured parenteral nutrition with vs without lipids: is the use of lipids really deleterious?. J Parenter Enteral Nutr 36 (2012), 421–430.
Kapoor, V., Glover, R., Malviya, M.N., Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants. Cochrane Database Syst Rev, 12, 2015, CD009172.
Robinson, D.T., Carlson, S.E., Murthy, K., Frost, B., Li, S., Caplan, M., Docosahexaenoic and arachidonic acid levels in extremely low birth weight infants with prolonged exposure to intravenous lipids. J Pediatr 162 (2013), 56–61.
Martin, C.R., Dasilva, D.A., Cluette-Brown, J.E., Dimonda, C., Hamill, A., Bhutta, A.Q., et al. Decreased postnatal docosahexaenoic and arachidonic acid blood levels in premature infants are associated with neonatal morbidities. J Pediatr, 159, 2011 743–9 e1–2.
Manzanares, W., Langlois, P.L., Dhaliwal, R., Lemieux, M., Heyland, D.K., Intravenous fish oil lipid emulsions in critically ill patients: an updated systematic review and meta-analysis. Crit Care, 19, 2015, 167.
Pradelli, L., Mayer, K., Muscaritoli, M., Heller, A.R., n-3 fatty acid-enriched parenteral nutrition regimens in elective surgical and ICU patients: a meta-analysis. Crit Care, 16, 2012, R184.
Finn, K.L., Chung, M., Rothpletz-Puglia, P., Byham-Gray, L., Impact of providing a combination lipid emulsion compared with a standard soybean oil lipid emulsion in children receiving parenteral nutrition: a systematic review and meta-analysis. J Parenter Enteral Nutr 39 (2015), 656–667.
Goulet, O.J., Intestinal failure-associated liver disease and the use of fish oil-based lipid emulsions. World Rev Nutr Diet 112 (2015), 90–114.
Lacaille, F., Gupte, G., Colomb, V., D'Antiga, L., Hartman, C., Hojsak, I., et al. Intestinal failure-associated liver disease: a position paper of the ESPGHAN working group of intestinal failure and intestinal transplantation. J Pediatr Gastroenterol Nutr 60 (2015), 272–283.
Goulet, O., Joly, F., Corriol, O., Colomb-Jung, V., Some new insights in intestinal failure-associated liver disease. Curr Opin Organ Transplant 14 (2009), 256–261.
Hojsak, I., Colomb, V., Braegger, C., Bronsky, J., Campoy, C., Domellof, M., et al., ESPGHAN Committee on Nutrition Position Paper. Intravenous lipid emulsions and risk of hepatotoxicity in infants and children: a systematic review and meta-analysis. J Pediatr Gastroenterol Nutr 62 (2016), 776–792.
Colomb, V., Jobert-Giraud, A., Lacaille, F., Goulet, O., Fournet, J.C., Ricour, C., Role of lipid emulsions in cholestasis associated with long-term parenteral nutrition in children. J Parenter Enteral Nutr 24 (2000), 345–350.
Diamond, I.R., de Silva, N.T., Tomlinson, G.A., Pencharz, P.B., Feldman, B.M., Moore, A.M., et al. The role of parenteral lipids in the development of advanced intestinal failure-associated liver disease in infants: a multiple-variable analysis. J Parenter Enteral Nutr 35 (2011), 596–602.
Koletzko, B., Goulet, O., Fish oil containing intravenous lipid emulsions in parenteral nutrition-associated cholestatic liver disease. Curr Opin Clin Nutr Metab Care 13 (2010), 321–326.
Sanchez, S.E., Braun, L.P., Mercer, L.D., Sherrill, M., Stevens, J., Javid, P.J., The effect of lipid restriction on the prevention of parenteral nutrition-associated cholestasis in surgical infants. J Pediatr Surg 48 (2013), 573–578.
Rollins, M.D., Ward, R.M., Jackson, W.D., Mulroy, C.W., Spencer, C.P., Ying, J., et al. Effect of decreased parenteral soybean lipid emulsion on hepatic function in infants at risk for parenteral nutrition-associated liver disease: a pilot study. J Pediatr Surg 48 (2013), 1348–1356.
Levit, O.L., Calkins, K.L., Gibson, L.C., Kelley-Quon, L., Robinson, D.T., Elashoff, D.A., et al. Low-dose intravenous soybean oil emulsion for prevention of cholestasis in preterm neonates. J Parenter Enteral Nutr 40 (2016), 374–382.
Nehra, D., Fallon, E.M., Carlson, S.J., Potemkin, A.K., Hevelone, N.D., Mitchell, P.D., et al. Provision of a soy-based intravenous lipid emulsion at 1 g/kg/d does not prevent cholestasis in neonates. J Parenter Enteral Nutr 37 (2013), 498–505.
Ong, M.L., Purdy, I.B., Levit, O.L., Robinson, D.T., Grogan, T., Flores, M., et al. Two-year neurodevelopment and growth outcomes for preterm neonates who received low-dose intravenous soybean oil. J Parenter Enteral Nutr 42 (2018), 352–360.
Pawlik, D., Lauterbach, R., Walczak, M., Hurkala, J., Sherman, M.P., Fish-oil fat emulsion supplementation reduces the risk of retinopathy in very low birth weight infants: a prospective, randomized study. J Parenter Enteral Nutr 38 (2013), 711–716.
Uthaya, S., Liu, X., Babalis, D., Dore, C.J., Warwick, J., Bell, J., et al. Nutritional evaluation and optimisation in neonates: a randomized, double-blind controlled trial of amino acid regimen and intravenous lipid composition in preterm parenteral nutrition. Am J Clin Nutr 103 (2016), 1443–1452.
Hartman, C., Ben-Artzi, E., Berkowitz, D., Elhasid, R., Lajterer, N., Postovski, S., et al. Olive oil-based intravenous lipid emulsion in pediatric patients undergoing bone marrow transplantation: a short-term prospective controlled trial. Clin Nutr 28 (2009), 631–635.
Nehra, D., Fallon, E.M., Potemkin, A.K., Voss, S.D., Mitchell, P.D., Valim, C., et al. A comparison of 2 intravenous lipid emulsions: interim analysis of a randomized controlled trial. J Parenter Enteral Nutr 38 (2014), 693–701.
Goulet, O., de Potter, S., Antebi, H., Driss, F., Colomb, V., Bereziat, G., et al. Long-term efficacy and safety of a new olive oil-based intravenous fat emulsion in pediatric patients: a double-blind randomized study. Am J Clin Nutr 70 (1999), 338–345.
Goulet, O., Antebi, H., Wolf, C., Talbotec, C., Alcindor, L.G., Corriol, O., et al. A new intravenous fat emulsion containing soybean oil, medium-chain triglycerides, olive oil, and fish oil: a single-center, double-blind randomized study on efficacy and safety in pediatric patients receiving home parenteral nutrition. J Parenter Enteral Nutr 34 (2010), 485–495.
Diamond, I.R., Grant, R.C., Pencharz, P.B., de Silva, N., Feldman, B.M., Fitzgerald, P., et al. Preventing the progression of intestinal failure-associated liver disease in infants using a composite lipid emulsion: a pilot randomized controlled trial of SMOF lipid. J Parenter Enteral Nutr 41 (2017), 866–877.
Lapillonne, A., Moltu, S.J., Long-chain polyunsaturated fatty acids and clinical outcomes of preterm infants. Ann Nutr Metab 69:Suppl. 1 (2016), 35–44.
Koksal, N., Kavurt, A.V., Cetinkaya, M., Ozarda, Y., Ozkan, H., Comparison of lipid emulsions on antioxidant capacity in preterm infants receiving parenteral nutrition. Pediatr Int 53 (2011), 562–566.
Roggero, P., Mosca, F., Gianni, M.L., Orsi, A., Amato, O., Migliorisi, E., et al. F2-isoprostanes and total radical-trapping antioxidant potential in preterm infants receiving parenteral lipid emulsions. Nutrition 26 (2010), 551–555.
Savini, S., D'Ascenzo, R., Biagetti, C., Serpentini, G., Pompilio, A., Bartoli, A., et al. The effect of 5 intravenous lipid emulsions on plasma phytosterols in preterm infants receiving parenteral nutrition: a randomized clinical trial. Am J Clin Nutr 98 (2013), 312–318.
Xu, Z., Harvey, K.A., Pavlina, T., Dutot, G., Hise, M., Zaloga, G.P., et al. Steroidal compounds in commercial parenteral lipid emulsions. Nutrients 4 (2012), 904–921.
Vasudevan, C., Johnson, K., Miall, L.S., Thompson, D., Puntis, J., The effect of parenteral lipid emulsions on pulmonary hemodynamics and eicosanoid metabolites in preterm infants: a pilot study. Nutr Clin Pract 28 (2013), 753–757.
van Kempen, A.A., van der Crabben, S.N., Ackermans, M.T., Endert, E., Kok, J.H., Sauerwein, H.P., Stimulation of gluconeogenesis by intravenous lipids in preterm infants: response depends on fatty acid profile. Am J Physiol Endocrinol Metab 290 (2006), E723–E730.
Vlaardingerbroek, H., Vermeulen, M.J., Carnielli, V.P., Vaz, F.M., van den Akker, C.H., van Goudoever, J.B., Growth and fatty acid profiles of VLBW infants receiving a multicomponent lipid emulsion from birth. J Pediatr Gastroenterol Nutr 58 (2014), 417–427.
Pawlik, D., Lauterbach, R., Turyk, E., Fish-oil fat emulsion supplementation may reduce the risk of severe retinopathy in VLBW infants. Pediatrics 127 (2011), 223–228.
Beken, S., Dilli, D., Fettah, N.D., Kabatas, E.U., Zenciroglu, A., Okumus, N., The influence of fish-oil lipid emulsions on retinopathy of prematurity in very low birth weight infants: a randomized controlled trial. Early Hum Dev 90 (2014), 27–31.
Skouroliakou, M., Konstantinou, D., Koutri, K., Kakavelaki, C., Stathopoulou, M., Antoniadi, M., et al. A double-blind, randomized clinical trial of the effect of omega-3 fatty acids on the oxidative stress of preterm neonates fed through parenteral nutrition. Eur J Clin Nutr 64 (2010), 940–947.
Skouroliakou, M., Konstantinou, D., Agakidis, C., Delikou, N., Koutri, K., Antoniadi, M., et al. Cholestasis, bronchopulmonary dysplasia, and lipid profile in preterm infants receiving MCT/omega-3-PUFA-containing or soybean-based lipid emulsions. Nutr Clin Pract 27 (2012), 817–824.
Martin, C.R., Zaman, M.M., Gilkey, C., Salguero, M.V., Hasturk, H., Kantarci, A., et al. Resolvin D1 and lipoxin A4 improve alveolarization and normalize septal wall thickness in a neonatal murine model of hyperoxia-induced lung injury. PLoS One, 9, 2014, e98773.
Biagetti, C., Vedovelli, L., Savini, S., Simonato, M., D'Ascenzo, R., Pompilio, A., et al. Double blind exploratory study on de novo lipogenesis in preterm infants on parenteral nutrition with a lipid emulsion containing 10% fish oil. Clin Nutr 35 (2016), 337–343.
Larsen, B.M., Field, C.J., Leong, A.Y., Goonewardene, L.A., Van Aerde, J.E., Joffe, A.R., et al. Pretreatment with an intravenous lipid emulsion increases plasma eicosapentanoic acid and downregulates leukotriene b4, procalcitonin, and lymphocyte concentrations after open heart surgery in infants. J Parenter Enteral Nutr 39 (2015), 171–179.
Baena-Gomez, M.A., Aguilar, M.J., Mesa, M.D., Navero, J.L., Gil-Campos, M., Changes in antioxidant defense system using different lipid emulsions in parenteral nutrition in children after hematopoietic stem cell transplantation. Nutrients 7 (2015), 7242–7255.
Baena-Gomez, M.A., de la Torre-Aguilar, M.J., Aguilera-Garcia, C.M., Olza, J., Perez-Navero, J.L., Gil-Campos, M., Inflammatory response using different lipid parenteral nutrition formulas in children after hematopoietic stem cell transplantation. Nutr Cancer 68 (2016), 804–810.
Skouroliakou, M., Konstantinou, D., Agakidis, C., Kaliora, A., Kalogeropoulos, N., Massara, P., et al. Parenteral MCT/omega-3 polyunsaturated fatty acid-enriched intravenous fat emulsion is associated with cytokine and fatty acid profiles consistent with attenuated inflammatory response in preterm neonates: a randomized, double-blind clinical trial. Nutr Clin Pract 31 (2016), 235–244.
Laborie, S., Denis, A., Dassieu, G., Bedu, A., Tourneux, P., Pinquier, D., et al. Shielding parenteral nutrition solutions from light: a randomized controlled trial. J Parenter Enteral Nutr 39 (2015), 729–737.
Khashu, M., Harrison, A., Lalari, V., Gow, A., Lavoie, J.C., Chessex, P., Photoprotection of parenteral nutrition enhances advancement of minimal enteral nutrition in preterm infants. Semin Perinatol 30 (2006), 139–145.
Stritzke, A., Turcot, V., Rouleau, T., Lavoie, J.C., Chessex, P., Influence of shielding TPN from photooxidation on the number of early blood transfusions in ELBW premature neonates. J Pediatr Gastroenterol Nutr 55 (2012), 398–402.
Khashu, M., Harrison, A., Lalari, V., Lavoie, J.C., Chessex, P., Impact of shielding parenteral nutrition from light on routine monitoring of blood glucose and triglyceride levels in preterm neonates. Arch Dis Child Fetal Neonatal Ed 94 (2009), F111–F115.
Nakanishi-Ueda, T., Majima, H.J., Watanabe, K., Ueda, T., Indo, H.P., Suenaga, S., et al. Blue LED light exposure develops intracellular reactive oxygen species, lipid peroxidation, and subsequent cellular injuries in cultured bovine retinal pigment epithelial cells. Free Radic Res 47 (2013), 774–780.
Roehlecke, C., Schumann, U., Ader, M., Brunssen, C., Bramke, S., Morawietz, H., et al. Stress reaction in outer segments of photoreceptors after blue light irradiation. PLoS One, 8, 2013, e71570.
Chessex, P., Laborie, S., Lavoie, J.C., Rouleau, T., Photoprotection of solutions of parenteral nutrition decreases the infused load as well as the urinary excretion of peroxides in premature infants. Semin Perinatol 25 (2001), 55–59.
Miloudi, K., Comte, B., Rouleau, T., Montoudis, A., Levy, E., Lavoie, J.C., The mode of administration of total parenteral nutrition and nature of lipid content influence the generation of peroxides and aldehydes. Clin Nutr 31 (2012), 526–534.
Bassiouny, M.R., Almarsafawy, H., Abdel-Hady, H., Nasef, N., Hammad, T.A., Aly, H., A randomized controlled trial on parenteral nutrition, oxidative stress, and chronic lung diseases in preterm infants. J Pediatr Gastroenterol Nutr 48 (2009), 363–369.
Jalabert, A., Grand, A., Steghens, J.P., Barbotte, E., Pigue, C., Picaud, J.C., Lipid peroxidation in all-in-one admixtures for preterm neonates: impact of amount of lipid, type of lipid emulsion and delivery condition. Acta Paediatr 100 (2011), 1200–1205.
Chessex, P., Laborie, S., Nasef, N., Masse, B., Lavoie, J.C., Shielding parenteral nutrition from light improves survival rate in premature infants: a meta-analysis. J Parenter Enteral Nutr 41 (2017), 378–383.
Lapillonne, A., Fellous, L., Kermorvant-Duchemin, E., Use of parenteral lipid emulsions in French neonatal ICUs. Nutr Clin Pract 26 (2011), 672–680.
Cowan, E., Nandivada, P., Puder, M., Fish oil-based lipid emulsion in the treatment of parenteral nutrition-associated liver disease. Curr Opin Pediatr 25 (2013), 193–200.
Salvador, A., Janeczko, M., Porat, R., Sekhon, R., Moewes, A., Schutzman, D., Randomized controlled trial of early parenteral nutrition cycling to prevent cholestasis in very low birth weight infants. J Pediatr 161 (2012), 229–233 e1.
Jensen, A.R., Goldin, A.B., Koopmeiners, J.S., Stevens, J., Waldhausen, J.H., Kim, S.S., The association of cyclic parenteral nutrition and decreased incidence of cholestatic liver disease in patients with gastroschisis. J Pediatr Surg 44 (2009), 183–189.
Nghiem-Rao, T.H., Cassidy, L.D., Polzin, E.M., Calkins, C.M., Arca, M.J., Goday, P.S., Risks and benefits of prophylactic cyclic parenteral nutrition in surgical neonates. Nutr Clin Pract 28 (2013), 745–752.
Stout, S.M., Cober, M.P., Metabolic effects of cyclic parenteral nutrition infusion in adults and children. Nutr Clin Pract 25 (2010), 277–281.
Driscoll, D.F., Commercial lipid emulsions and all-in-one mixtures for intravenous infusion – composition and physicochemical properties. World Rev Nutr Diet 112 (2015), 48–56.
Boullata, J.I., Gilbert, K., Sacks, G., Labossiere, R.J., Crill, C., Goday, P., et al. A.S.P.E.N. clinical guidelines: parenteral nutrition ordering, order review, compounding, labeling, and dispensing. J Parenter Enteral Nutr 38 (2014), 334–377.
Hernandez Prats, C., Panisello, M.R., Fuentes Bonmati, M.J., Torres Chazarra, C., Sanchez Casado, M.I., Lipid destabilisation in a ternary admixture for paediatric parenteral nutrition due to heparin and trigger factors. Farmac Hosp 36 (2012), 159–162.
Silvers, K.M., Darlow, B.A., Winterbourn, C.C., Pharmacologic levels of heparin do not destabilize neonatal parenteral nutrition. J Parenter Enteral Nutr 22 (1998), 311–314.
Crill, C.M., Helms, R.A., The use of carnitine in pediatric nutrition. Nutr Clin Pract 22 (2007), 204–213.
Winther, B., Jackson, D., Mulroy, C., MacKay, M., Evaluation of serum carnitine levels for pediatric patients receiving carnitine-free and carnitine-supplemented parenteral nutrition. Hosp Pharm 49 (2014), 549–553.
Crill, C.M., Storm, M.C., Christensen, M.L., Hankins, C.T., Bruce Jenkins, M., Helms, R.A., Carnitine supplementation in premature neonates: effect on plasma and red blood cell total carnitine concentrations, nutrition parameters and morbidity. Clin Nutr 25 (2006), 886–896.
Pande, S., Brion, L.P., Campbell, D.E., Gayle, Y., Esteban-Cruciani, N.V., Lack of effect of L-carnitine supplementation on weight gain in very preterm infants. J Perinatol 25 (2005), 470–477.
Seong, S.H., Cho, S.C., Park, Y., Cha, Y.S., L-carnitine-supplemented parenteral nutrition improves fat metabolism but fails to support compensatory growth in premature Korean infants. Nutr Res 30 (2010), 233–239.
Borum, P.R., Carnitine in parenteral nutrition. Gastroenterology 137 (2009), S129–S134.
Joffe, A., Anton, N., Lequier, L., Vandermeer, B., Tjosvold, L., Larsen, B., et al. Nutritional support for critically ill children. Cochrane Database Syst Rev, 2016, CD005144.
Fivez, T., Kerklaan, D., Mesotten, D., Verbruggen, S., Wouters, P.J., Vanhorebeek, I., et al. Early versus late parenteral nutrition in critically ill children. N Engl J Med 374 (2016), 1111–1122.
Bechard, L.J., Duggan, C., Touger-Decker, R., Parrott, J.S., Rothpletz-Puglia, P., Byham-Gray, L., et al. Nutritional status based on body mass index is associated with morbidity and mortality in mechanically ventilated critically ill children in the PICU. Crit Care Med 44 (2016), 1530–1537.
Hasselmann, M., Reimund, J.M., Lipids in the nutritional support of the critically ill patients. Curr Opin Crit Care 10 (2004), 449–455.
Houeijeh, A., Aubry, E., Coridon, H., Montaigne, K., Sfeir, R., Deruelle, P., et al. Effects of n-3 polyunsaturated fatty acids in the fetal pulmonary circulation. Crit Care Med 39 (2011), 1431–1438.
Beghin, L., Storme, L., Coopman, S., Rakza, T., Gottrand, F., Parenteral nutrition with fish oil supplements is safe and seems to be effective in severe preterm neonates with respiratory distress syndrome. Acta Paediatr 104 (2015), e534–e536.
Singer, P., Theilla, M., Fisher, H., Gibstein, L., Grozovski, E., Cohen, J., Benefit of an enteral diet enriched with eicosapentaenoic acid and gamma-linolenic acid in ventilated patients with acute lung injury. Crit Care Med 34 (2006), 1033–1038.
Pacht, E.R., DeMichele, S.J., Nelson, J.L., Hart, J., Wennberg, A.K., Gadek, J.E., Enteral nutrition with eicosapentaenoic acid, gamma-linolenic acid, and antioxidants reduces alveolar inflammatory mediators and protein influx in patients with acute respiratory distress syndrome. Crit Care Med 31 (2003), 491–500.
Larsen, B.M., Goonewardene, L.A., Joffe, A.R., Van Aerde, J.E., Field, C.J., Olstad, D.L., et al. Pre-treatment with an intravenous lipid emulsion containing fish oil (eicosapentaenoic and docosahexaenoic acid) decreases inflammatory markers after open-heart surgery in infants: a randomized, controlled trial. Clin Nutr 31 (2012), 322–329.
Miles, E.A., Calder, P.C., Fatty acids, lipid emulsions and the immune and inflammatory systems. World Rev Nutr Diet 112 (2015), 17–30.
Powis, M.R., Smith, K., Rennie, M., Halliday, D., Pierro, A., Effect of major abdominal operations on energy and protein metabolism in infants and children. J Pediatr Surg 33 (1998), 49–53.
Cave, G., Harvey, M., Graudins, A., Intravenous lipid emulsion as antidote: a summary of published human experience. Emerg Med Australas 23 (2011), 123–141.
Ozcan, M.S., Weinberg, G., Intravenous lipid emulsion for the treatment of drug toxicity. J Intensive Care Med 29 (2014), 59–70.
Eizaga Rebollar, R., Garcia Palacios, M.V., Morales Guerrero, J., Torres Morera, L.M., Lipid rescue in children: the prompt decision. J Clin Anesth 32 (2016), 248–252.
Presley, J.D., Chyka, P.A., Intravenous lipid emulsion to reverse acute drug toxicity in pediatric patients. Ann Pharmacother 47 (2013), 735–743.
Hojsak, I., Kolacek, S., Fat overload syndrome after the rapid infusion of SMOF lipid emulsion. J Parenter Enteral Nutr 38 (2014), 119–121.
Puder, M., Valim, C., Meisel, J.A., Le, H.D., de Meijer, V.E., Robinson, E.M., et al. Parenteral fish oil improves outcomes in patients with parenteral nutrition-associated liver injury. Ann Surg 250 (2009), 395–402.
Diamond, I.R., Sterescu, A., Pencharz, P.B., Kim, J.H., Wales, P.W., Changing the paradigm: omegaven for the treatment of liver failure in pediatric short bowel syndrome. J Pediatr Gastroenterol Nutr 48 (2009), 209–215.
Muhammed, R., Bremner, R., Protheroe, S., Johnson, T., Holden, C., Murphy, M.S., Resolution of parenteral nutrition-associated jaundice on changing from a soybean oil emulsion to a complex mixed-lipid emulsion. J Pediatr Gastroenterol Nutr 54 (2012), 797–802.
Lai, H., Chen, W., Effects of medium-chain and long-chain triacylglycerols in pediatric surgical patients. Nutrition 16 (2000), 401–406.
Lam, H.S., Tam, Y.H., Poon, T.C., Cheung, H.M., Yu, X., Chan, B.P., et al. A double-blind randomised controlled trial of fish oil-based versus soy-based lipid preparations in the treatment of infants with parenteral nutrition-associated cholestasis. Neonatology 105 (2014), 290–296.
Park, H.W., Lee, N.M., Kim, J.H., Kim, K.S., Kim, S.N., Parenteral fish oil-containing lipid emulsions may reverse parenteral nutrition-associated cholestasis in neonates: a systematic review and meta-analysis. J Nutr 145 (2015), 277–283.
Mertes, N., Grimm, H., Furst, P., Stehle, P., Safety and efficacy of a new parenteral lipid emulsion (SMOFlipid) in surgical patients: a randomized, double-blind, multicenter study. Ann Nutr Metab 50 (2006), 253–259.
Antebi, H., Mansoor, O., Ferrier, C., Tetegan, M., Morvan, C., Rangaraj, J., et al. Liver function and plasma antioxidant status in intensive care unit patients requiring total parenteral nutrition: comparison of 2 fat emulsions. J Parenter Enteral Nutr 28 (2004), 142–148.
Matsumoto, C.S., Kaufman, S.S., Island, E.R., Kallakury, B., Yazigi, N.A., Khan, K.M., et al. Hepatic explant pathology of pediatric intestinal transplant recipients previously treated with omega-3 fatty acid lipid emulsion. J Pediatr 165 (2014), 59–64.
Mercer, D.F., Hobson, B.D., Fischer, R.T., Talmon, G.A., Perry, D.A., Gerhardt, B.K., et al. Hepatic fibrosis persists and progresses despite biochemical improvement in children treated with intravenous fish oil emulsion. J Pediatr Gastroenterol Nutr 56 (2013), 364–369.
Xu, Z., Li, Y., Wang, J., Wu, B., Li, J., Effect of omega-3 polyunsaturated fatty acids to reverse biopsy-proven parenteral nutrition-associated liver disease in adults. Clin Nutr 31 (2012), 217–223.
Premkumar, M.H., Carter, B.A., Hawthorne, K.M., King, K., Abrams, S.A., Fish oil-based lipid emulsions in the treatment of parenteral nutrition-associated liver disease: an ongoing positive experience. Adv Nutr 5 (2014), 65–70.
Angsten, G., Finkel, Y., Lucas, S., Kassa, A.M., Paulsson, M., Lilja, H.E., Improved outcome in neonatal short bowel syndrome using parenteral fish oil in combination with omega-6/9 lipid emulsions. J Parenter Enteral Nutr 36 (2012), 587–595.
Le, H.D., de Meijer, V.E., Robinson, E.M., Zurakowski, D., Potemkin, A.K., Arsenault, D.A., et al. Parenteral fish-oil-based lipid emulsion improves fatty acid profiles and lipids in parenteral nutrition-dependent children. Am J Clin Nutr 94 (2011), 749–758.
Nehra, D., Fallon, E.M., Potemkin, A.K., Voss, S.D., Mitchell, P.D., Valim, C., et al. A comparison of 2 intravenous lipid emulsions: interim analysis of a randomized controlled trial. J Parenter Enter Nutr 38 (2013), 693–701.
Turner, J.M., Field, C.J., Goruk, S., Wizzard, P., Dicken, B.J., Bruce, A., et al. Platelet arachidonic acid deficiency may contribute to abnormal platelet function during parenteral fish oil monotherapy in a piglet model. J Parenter Enter Nutr 40 (2016), 587–591.
Dicken, B.J., Bruce, A., Samuel, T.M., Wales, P.W., Nahirniak, S., Turner, J.M., Bedside to bench: the risk of bleeding with parenteral omega-3 lipid emulsion therapy. J Pediatr 164 (2014), 652–654.
