Doctoral thesis (Dissertations and theses)
Inactivation of DNA damage repair provides additional efficacy to the treatment of thyroid cancer
Neelature Sriramareddy, Sathyanarayana
2017
 

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Keywords :
Thyroid cancer; DNA damage repair pathways; Circulating tumor cells
Abstract :
[en] Incidence of thyroid cancer has increased steadily over the last several decades. This type of neoplasm accounts for the majority of deaths due to endocrine cancers. The most frequent form, well-differentiated thyroid cancer, is characterized by disease persistence, recurrence and a lack of response to radioiodine-131. With survival rates of 9 weeks to 5 months, anaplastic thyroid cancer has very poor prognosis. To provide additional efficacy to the treatment of thyroid cancer, we investigated the mechanisms of DNA damage and repair. We found that thyroid cancer cells undergo mitosis in presence of unrepaired DNA damage. To proliferate and survive, these cells repair DNA lesions very efficiently using homologous recombination (HR) and non-homologous end joining (NHEJ). Pharmacological inhibition of these pathways significantly increases apoptosis of thyroid cancer cells. This thesis thus demonstrates that targeting DNA damage repair pathways might have therapeutic value in relapsing and advanced thyroid cancers.
Research center :
Agronomie, Bioingénierie et Chimie - AgroBioChem
Disciplines :
Oncology
Author, co-author :
Neelature Sriramareddy, Sathyanarayana ;  Université de Liège - ULiège > Form. doct. sc. agro. & ingé. biol.
Language :
English
Title :
Inactivation of DNA damage repair provides additional efficacy to the treatment of thyroid cancer
Defense date :
24 March 2017
Number of pages :
124
Institution :
ULiège - Université de Liège
Degree :
Docteur en Sciences agronomiques et Ingénierie biologique
Promotor :
Willems, Luc  ;  Université de Liège - ULiège > Département GxABT
President :
Fauconnier, Marie-Laure  ;  Université de Liège - ULiège > Département GxABT
Jury member :
Habraken, Yvette ;  Université de Liège - ULiège > GIGA > GIGA Molecular Biology of Diseases - Gene Expression & Cancer
Massart, Sébastien  ;  Université de Liège - ULiège > Département GxABT > Gestion durable des bio-agresseurs
HAMOIR, Etienne ;  Université de Liège - ULiège > Département des sciences cliniques
Barez, Pierre-Yves
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since 20 March 2017

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