[en] In this study, we report the genetic diversity and
nucleotide mutation rates of five representative regions of
the murine norovirus genome during in vitro passages. The
mutation rates were similar in genomic regions encompassing
partial coding sequences for non-structural (NS)
1-2, NS5, NS6, NS7 proteins within open reading frame
(ORF) 1. In a region encoding a portion of the major capsid
protein (VP1) within ORF2 (also including the ORF4
region) and a portion of the minor structural protein (VP2),
the mutation rates were estimated to be at least one order of
magnitude higher. The VP2 coding region was found to
have the highest mutation rate.
Research center :
FARAH - Fundamental and Applied Research for Animals and Health - ULiège
Disciplines :
Microbiology
Author, co-author :
Mauroy, Axel ; Université de Liège > Département des maladies infectieuses et parasitaires (DMI) > Virologie vétérinaire et maladies virales animales
Taminiau, Bernard ; Université de Liège > Département de sciences des denrées alimentaires (DDA) > Microbiologie des denrées alimentaires
Nezer, Carine
Ghurburrun, Elsa
Baurain, Denis ; Université de Liège > Département des sciences de la vie > Phylogénomique des eucaryotes
Daube, Georges ; Université de Liège > Département de sciences des denrées alimentaires (DDA) > Microbiologie des denrées alimentaires
Thiry, Etienne ; Université de Liège > Département des maladies infectieuses et parasitaires (DMI) > Virologie vétérinaire et maladies virales animales
Language :
English
Title :
High-throughput sequencing analysis reveals the genetic diversity of different regions of the murine norovirus genome during in vitro replication
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