Article (Scientific journals)
Mussel-inspired protein-repelling ambivalent block copolymers: controlled synthesis and characterization
Patil, Nagaraj; Falentin-Daudré, Céline; Jérôme, Christine et al.
2015In Polymer Chemistry, 6 (15), p. 2919-2933
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Keywords :
radical polymerization; reversible addition-fragmentation polymerization (RAFT)
Abstract :
[en] This paper describes the reversible addition–fragmentation chain transfer (RAFT) polymerization of mussel-inspired acetonide-protected dopamine (meth)acrylamide monomers (ADA and ADMA) and its implementation to the synthesis of innovative ambivalent block copolymers. They consist of a hydro- phobic poly((meth)acrylamide) block functionalized by catechols and a hydrophilic segment of a poly- ((meth)acrylate) bearing pendent PEG chains. For the first time, a series of well-defined P(PEGAm-b-ADAn) and P(ADMAn-b-PEGMAm) diblock copolymers across a range of molar masses (13–42 kg mol−1) with low molar mass dispersities (Đ = 1.12 − 1.25) were reported. Post polymerization, trifluoroacetic acid (TFA) treatment yields block copolymers bearing free-catechol units in quantitative yields (>95%) with a slight noticeable hydrolysis of pendent-PEG units (2%–4%). The self-assembly of the amphiphilic block copoly- mers into spherical micelles was demonstrated by 1H NMR, DLS and TEM imaging techniques. Real-time quartz crystal microbalance with dissipation monitoring (QCM-D) studies revealed that free-catechol groups were necessary for a strong anchoring onto gold and stainless steel surfaces because acetonide- protected and catechol-oxidized block copolymers completely desorbed from the surface in the rinsing step. The ambivalent nature of catechol functionalized block copolymers was studied by bovine serum albumin (BSA) adsorption on polymer modified surfaces, which displayed improved resistance against BSA adsorption, when compared to an unmodified surface.
Research center :
Center for Education and Research on Macromolecules (CERM)
Disciplines :
Chemistry
Materials science & engineering
Author, co-author :
Patil, Nagaraj ;  University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Falentin-Daudré, Céline;  University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Jérôme, Christine  ;  University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Detrembleur, Christophe ;  University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Language :
English
Title :
Mussel-inspired protein-repelling ambivalent block copolymers: controlled synthesis and characterization
Publication date :
21 April 2015
Journal title :
Polymer Chemistry
ISSN :
1759-9954
eISSN :
1759-9962
Publisher :
Royal Society Chemistry, Cambridge, United Kingdom
Volume :
6
Issue :
15
Pages :
2919-2933
Peer reviewed :
Peer Reviewed verified by ORBi
European Projects :
FP7 - 289347 - RENAISSANCE - TRAINING NETWORK IN INNOVATIVE POLYELECTROLYTES FOR ENERGY AND ENVIRONMENT
Funders :
BELSPO - SPP Politique scientifique - Service Public Fédéral de Programmation Politique scientifique
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
CE - Commission Européenne [BE]
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