[en] BACKGROUND:
Detecting signs of consciousness in patients in a vegetative state/unresponsive wakefulness syndrome (UWS/VS) or minimally conscious state (MCS) is known to be very challenging. Plotkin et al. (2010) recently showed the possibility of using a breathing-controlled communication device in patients with locked in syndrome. We here aim to test a breathing-based "sniff controller" that could be used as an alternative diagnostic tool to evaluate response to command in severely brain damaged patients with chronic disorders of consciousness (DOC).
METHODS:
Twenty-five DOC patients were included. Patients' resting breathing-amplitude was measured during a 5 min resting condition. Next, they were instructed to end the presentation of a music sequence by sniffing vigorously. An automated detection of changes in breathing amplitude (i.e., >1.5 SD of resting) ended the music and hence provided positive feedback to the patient.
RESULTS:
None of the 11 UWS/VS patients showed a sniff-based response to command. One out of 14 patients with MCS was able to willfully modulate his breathing pattern to answer the command on 16/19 trials (accuracy 84%). Interestingly, this patient failed to show any other motor response to command.
DISCUSSION:
We here illustrate the possible interest of using breathing-dependent response to command in the detection of residual cognition in patients with DOC after severe brain injury.
Lesenfants, Damien; Université de Liège - ULiège > Centre de recherches du cyclotron
Sela, Lee; The Weizmann Institute of Science > Department of Neurobiology
Noirhomme, Quentin; Brain Innovation B.V.
Ziegler, Erik ; University of Liège > Centre de recherches du cyclotron
Chatelle, Camille ; Université de Liège - ULiège > Centre de recherches du cyclotron
Plotkin, Anton; The Weizmann Institute of Science > Department of Neurobiology
Sobel, Noam; The Weizmann Institute of Science > Department of Neurobiology
Laureys, Steven ; Université de Liège - ULiège > Centre de recherches du cyclotron
Language :
English
Title :
Detection of response to command using voluntary control of breathing in disorders of consciousness
Publication date :
23 December 2014
Journal title :
Frontiers in Human Neuroscience
eISSN :
1662-5161
Publisher :
Frontiers Research Foundation, Lausanne, Switzerland
Volume :
8
Issue :
1020
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE] DG RDT - Commission Européenne. Direction Générale de la Recherche et de l'Innovation [BE] JSMF - James S McDonnell Foundation [US-MO] MSF - Mind Science Foundation [US-TX] French Speaking Community Concerted Research Action
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