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Human Exposure of Bisphenol A: Review of the Urinary Biomarker Levels in the General Population
PIRARD, Catherine; Charlier, Corinne
2014In Gibert, Yann (Ed.) Bisphenol A: Sources, Risks of Environmental Exposure and Human Health Effects
 

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Keywords :
BPA, urinary levels, general population
Abstract :
[en] Bipshenol A (2,2’-bis-[4-hydroxyphenyl]propane) involved as monomer in the manufacture of polycarbonate plastics and epoxy resins, is found in a wide variety of products including food packaging, baby bottles, food and drink cans or containers. Because of the migration of bisphenol A from the food container to the food itself, the dietary ingestion has been estimated to be the main source for the general population. The Human exposure is increasingly studied either through the determination of dietary intake or more frequently via the measurement of urinary biomarker. This chapter is reporting results from roughly 200 publications dedicated to the bisphenol A levels found in the urine of the worldwide general population and measured within the different Human biomonitoring (HBM) studies conducted in this last decade. The exposure of children and pregnant women, both known as particularly vulnerable populations, is separately examined. The impact of the different legislations implemented in different countries to reduce children’s exposure on one hand and the different campaigns dedicated to the general public on the other hand, is not observed yet through temporal trend, likely because of the quite recent character of these actions. The advantages and the limitations of biomonitoring studies are also addressed, like the high within-person variability, the difficulties to access to reliable analytical techniques, the poor inter-study comparability, and the current need of longitudinal studies to establish links between BPA exposure and chronic diseases.
Disciplines :
Chemistry
Pharmacy, pharmacology & toxicology
Author, co-author :
PIRARD, Catherine  ;  Centre Hospitalier Universitaire de Liège - CHU > Toxicologie clinique
Charlier, Corinne  ;  Université de Liège - ULiège > Département de pharmacie > Chimie toxicologique
Language :
English
Title :
Human Exposure of Bisphenol A: Review of the Urinary Biomarker Levels in the General Population
Publication date :
2014
Main work title :
Bisphenol A: Sources, Risks of Environmental Exposure and Human Health Effects
Editor :
Gibert, Yann
Publisher :
Nova Science Publishers
Pages :
125-154
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