Poster (Scientific congresses and symposiums)
[18F]UCB-H AS A NEW PET RADIOTRACER FOR SYNAPTIC VESICLE PROTEIN 2A
Bahri, Mohamed Ali; Bastin, Christine; Aerts, Joël et al.
2014European Molecular Imaging Meeting - EMIM 2014
 

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Keywords :
SV2A; Brain Imaging; epilepsy
Abstract :
[en] Synaptic vesicle protein 2A (SV2A) is widely distributed in the brain and has been demonstrated to be involved in vesicle trafficking. The critical role of SV2A in proper nervous system function is shown, for example, by the fact that it is a binding site and the primary mechanism of levetiracetam. Levetiracetam is an antiepileptic drug which has recently been suggested to reduce synaptic deficits in a mouse model for Alzheimer’s disease and to improve cognition in patients with amnestic mild cognitive impairment. We here aimed to investigate the cerebral distribution of [18F]UCB-H, a fluorine-18 radiolabelled PET imaging tracer, which has a high affinity with the SV2A. [18F]UCB-H was radiosynthesized under GMP conditions. Dynamic PET data of the head of four healthy volunteers were acquired over 100 minutes after injection of 170.4 ± 24.9 MBq of [18F]UCB-H. The arterial input function was obtained by blood sampling during the dynamic PET acquisition. The analysis of the blood data reveled a consistent amount of [18F]UCB-H in whole blood and plasma which indicates a very low degree of binding of the tracer to the red blood cells. The unchanged fraction of [18F]UCB-H in plasma showed a bi-exponential behavioral decrease with a starting fraction of 92% of the injected amount of the tracer, measured at 3 min post injection. This fraction decreased to about 50% at 10 min post injection. The [18F]UCB-H PET data showed a high and rapid uptake in the grey matter structures, matching the known ubiquitous distribution of the SV2A in the brain. The kinetics of the tracer in the brain was characterized by an initial high uptake phase followed by rapid washout allowing the standard compartmental modeling (1-tissue compartment, 2-tissue compartment, and Logan graphical analysis). The three models gave consistent results. The two-tissue compartment model fitted the experimental data best and provided a total distribution volume of the [18F]UCB-H in the brain greater than 7 mL/cm3 and a specific distribution volume around 3 mL/cm3. Our results suggest that [18F]UCB-H is a good candidate as radiotracer for brain SV2A proteins and could be used for human studies. In the future, SV2A modifications might be assessed in neurological pathologies such as Alzheimer’s disease.
Research center :
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège
Disciplines :
Radiology, nuclear medicine & imaging
Author, co-author :
Bahri, Mohamed Ali  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Bastin, Christine  ;  Université de Liège - ULiège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn.
Aerts, Joël ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Bretin, Florian ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Warnock, Geoffery
Buchanan, Tim;  UCB Pharma
Mella, Christine ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Mestdagh, Nathalie;  UCB Pharma
Otoul, Christian;  UCB Pharma
Koester, Franz;  UCB Pharma
Valade, Anne;  UCB Pharma
Mercier, Joël;  UCB Pharma
Lemaire, Christian ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Giacomelli, Fabrice ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Mievis, Frédéric ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Léonard, Marc
Seret, Alain ;  Université de Liège - ULiège > Département de physique > Imagerie médicale expérimentale
Luxen, André ;  Université de Liège - ULiège > Département de chimie (sciences) > Laboratoire de chimie organique de synthèse
Plenevaux, Alain  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Salmon, Eric  ;  Université de Liège - ULiège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn.
More authors (10 more) Less
Language :
English
Title :
[18F]UCB-H AS A NEW PET RADIOTRACER FOR SYNAPTIC VESICLE PROTEIN 2A
Publication date :
06 June 2014
Event name :
European Molecular Imaging Meeting - EMIM 2014
Event place :
Antwerp, Belgium
Event date :
4-6-2014 to 6-6-2014
Audience :
International
Funders :
This research was supported by FRS FNRS and by the PPP “Neurocom”, Walloon Region, between CRC-ULg and UCB Pharma.
Available on ORBi :
since 13 June 2014

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