DEMENTIA; NEUROIMAGING; SELF; SOCIAL COGNITION; UNAWARENESS
Abstract :
[en] Anosognosia is a complex symptom corresponding to a lack of awareness of one’s current clinical status. Anosognosia for cognitive deficits has frequently been described in Alzheimer’s disease (AD), while unawareness of current characteristics of personality traits has rarely been considered. We used a well-established questionnaire-based method in a group of 37 AD patients and in healthy controls to probe self- and hetero-evaluation of patients’ personality and we calculated differential scores between each participant’s and his/her relative’s judgments. A brain-behavior correlation was performed using FDG-PET images. The behavioral data showed that AD patients presented with anosognosia for current characteristics of their personality and their anosognosia was primarily explained by impaired third perspective taking. The brain-behavior correlation analysis revealed a negative relationship between anosognosia for current characteristics of personality and dorsomedial prefrontal cortex (dMPFC) activity. Behavioral and neuroimaging data are consistent with the view that impairment of different functions subserved by the dMPFC (self-evaluation, inferences regarding complex enduring dispositions of self and others, confrontation of perspectives in interpersonal scripts) plays a role in anosognosia for current characteristics of personality in AD patients.
Research center :
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège
Disciplines :
Neurology
Author, co-author :
Jedidi, Haroun ; Université de Liège - ULiège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn.
Feyers, Dorothée ; Université de Liège - ULiège > Département Psychologies et cliniques des systèmes humains > Psychologie de la sénescence
Collette, Fabienne ; Université de Liège - ULiège > Département de Psychologie : cognition et comportement > Neuropsychologie
Bahri, Mohamed Ali ; Université de Liège - ULiège > Centre de recherches du cyclotron
Jaspar, Mathieu ; Université de Liège - ULiège > Département de Psychologie : cognition et comportement > Neuropsychologie
D'Argembeau, Arnaud ; Université de Liège - ULiège > Département de Psychologie : cognition et comportement > Psychopathologie cognitive
Salmon, Eric ; Université de Liège - ULiège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn.
Bastin, Christine ; Université de Liège - ULiège > Centre de recherches du cyclotron
Language :
English
Title :
Dorsomedial prefrontal metabolism and unawareness of current characteristics of personality traits in Alzheimer’s disease
Publication date :
2014
Journal title :
Social Cognitive and Affective Neuroscience
ISSN :
1749-5016
eISSN :
1749-5024
Publisher :
Oxford University Press, Oxford, United Kingdom
Volume :
9
Issue :
10
Pages :
1458-1463
Peer reviewed :
Peer Reviewed verified by ORBi
Name of the research project :
Mécanismes de l'anosognosie, une étude sémiologique et par imagerie fonctionnelle.
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
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