Article (Scientific journals)
Characterization of porous polylactide foams by image analysis and impedance spectroscopy
Maquet, Véronique; Blacher, Silvia; Pirard, René et al.
2000In Langmuir, 16 (26), p. 10463-10470
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Keywords :
biomaterial; scaffold; foam
Abstract :
[en] The texture of highly porous polylactide foams prepared by freeze-drying of poly-L-lactide (L-PLA) and poly-DL-lactide (DL-PLA) solutions of various concentrations was investigated by two novel methodologies, image analysis and impedance spectroscopy. Image analysis of scanning electron micrographs of transverse cross-sections at two different magnifications gave information on both the macroporosity (1 mum < width 10 <mu>m) and ultramacroporosity (width > 10 mum). Impedance spectroscopy was used to investigate the transport properties of the three-dimensional porous matrices by measurement of ionic conduction. Image analysis showed that: (a) the macroporosity, which mainly contributes to porosity, is independent of the sample composition; (b) when the concentration of the polymer solution is increased, the density of the ultramacropores decreases and their average diameter increases; (c) the distribution of the ultramacropores is more homogeneous in the semicrystalline L-PLA. foams than in the amorphous DL-PLA counterparts, in which the ultramacropores tend to make clusters. The dielectric properties changed at low frequency, in relation to modifications in the ultramacroporosity. Ultramacropores of the L-PLA foams were found to be more open and more sensitive to the concentration of the polymer solutions compared with DL-PLA. Expectedly, the mechanical properties of the PLA foams changed with the structure of the ultramacroporous network. These results encourage further investigations on the texture of porous supports, to collect pertinent information on the physical macro- and ultramacroenvironment in which cells will reside.
Research center :
Center for Education and Research on Macromolecules (CERM)
Disciplines :
Physics
Materials science & engineering
Chemistry
Chemical engineering
Author, co-author :
Maquet, Véronique;  Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Blacher, Silvia ;  Université de Liège - ULiège > Department of Applied Chemistry > Laboratory of Chemical Engineering
Pirard, René ;  Université de Liège - ULiège > Département de chimie appliquée > Génie chimique - Chimie physique appliquée
Pirard, Jean-Paul ;  Université de Liège - ULiège > Department of Applied Chemistry > Laboratory of Chemical Engineering
Jérôme, Robert ;  Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Language :
English
Title :
Characterization of porous polylactide foams by image analysis and impedance spectroscopy
Publication date :
26 December 2000
Journal title :
Langmuir
ISSN :
0743-7463
eISSN :
1520-5827
Publisher :
American Chemical Society, Washington, United States - District of Columbia
Volume :
16
Issue :
26
Pages :
10463-10470
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
BELSPO - SPP Politique scientifique - Service Public Fédéral de Programmation Politique scientifique
The "Conseil de la Recherche" (University of Liège, ULg)
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