Article (Scientific journals)
Voxel-based distribution of metabolic impairment in corticobasal degeneration
Garraux, Gaëtan; Salmon, Eric; Peigneux, Philippe et al.
2000In Movement Disorders, 15 (5), p. 894-904
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Keywords :
Corticobasal degeneration; Progressive supranuclear palsy; PET
Abstract :
[en] This report emphasizes the precise topographic distribution of cerebral metabolic impairment in corticobasal degeneration (CBD) and the pathophysiological differences between CBD and progressive supranuclear palsy (PSP). Statistical parametric mapping (SPM96) analysis of 18FDG positron emission tomography (PET) data was performed in 22 patients with CBD compared with 46 healthy subjects (HS) and 21 patients with PSP who were studied at rest. A statistical threshold of p <0.001 was fixed, further corrected for multiple or independent comparisons (p <0.05). In comparison with HS, the metabolic impairment in CBD was asymmetrically distributed in the putamen, thalamus, precentral (Brodmann's area, BA 4), lateral premotor (BA 6/44) and supplementary motor areas (SMA, BA 6), dorsolateral prefrontal (8/9/46) cortex, and the anterior part of the inferior parietal lobe (BA 40) including the intraparietal sulcus (BA 7/40). A similar hypometabolic pattern was observed for most individual analyses. When PSP was compared with CBD, metabolic impairment predominated in the midbrain, anterior cingulate (BA 24/32), and orbitofrontal regions (BA 10). The reverse contrast showed more posterior involvement in CBD (BA 6 and 5/7/40) including SMA. Our data suggest that multiple components of neural networks related to both movement execution and production of skilled movements are functionally disturbed in CBD compared with both HS and PSP.
Research center :
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège
Disciplines :
Neurology
Radiology, nuclear medicine & imaging
Neurosciences & behavior
Author, co-author :
Garraux, Gaëtan  ;  Université de Liège - ULiège > Centre de Recherches du Cyclotron et Département des sciences cliniques > Neurologie
Salmon, Eric  ;  Université de Liège - ULiège > Centre de Recherches du Cyclotron et Département des sciences cliniques > Neurologie
Peigneux, Philippe ;  Université de Liège - ULiège > Centre de Recherches du Cyclotron et Département des sciences cognitives
Kreisler, Alexandre;  Université de Lille > CHRU > Neurologie
Degueldre, Christian ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Lemaire, Christian ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Destee, Alain;  Université de Lille > CHRU > Neurologie
Franck, Georges ;  Université de Liège - ULiège > Département des sciences cliniques > Neurologie
Language :
English
Title :
Voxel-based distribution of metabolic impairment in corticobasal degeneration
Publication date :
September 2000
Journal title :
Movement Disorders
ISSN :
0885-3185
eISSN :
1531-8257
Publisher :
John Wiley & Sons
Volume :
15
Issue :
5
Pages :
894-904
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Available on ORBi :
since 16 April 2009

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