[en] Autobiographical memory in amnestic Mild Cognitive Impairment (aMCI) is characterized by impaired retrieval of episodic memories, but relatively preserved personal semantic knowledge. This study aimed to identify (via FDG-PET) the neural substrates of impaired episodic specificity of autobiographical memories in 35 aMCI patients compared with 24 healthy elderly controls. Significant correlations between regional cerebral activity and the proportion of episodic details in autobiographical memories from two life periods were found in specific regions of an autobiographical brain network. In aMCI patients, more than in controls, specifically episodic memories from early adulthood were associated with metabolic activity in the cuneus and in parietal regions. We hypothesized that variable retrieval of episodic autobiographical memories in our aMCI patients would be related to their variable capacity to reactivate specific sensory-perceptual and contextual details of early adulthood events linked to reduced (occipito-parietal) visual imagery and less efficient (parietal) attentional processes. For recent memories (last year), a correlation emerged between the proportion of episodic details and activity in lateral temporal regions and the temporo-parietal junction. Accordingly, variable episodic memory for recent events may be related to the efficiency of controlled search through general events likely to provide cues for the retrieval of episodic details and to the ability to establish a self perspective favouring recollection.
Disciplines :
Neurosciences & behavior
Author, co-author :
Bastin, Christine ; Université de Liège - ULiège > Centre de recherches du cyclotron
Feyers, Dorothée ; Université de Liège - ULiège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn.
Jedidi, Haroun ; Université de Liège - ULiège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn.
Bahri, Mohamed Ali ; Université de Liège - ULiège > Centre de recherches du cyclotron
Degueldre, Christian ; Université de Liège - ULiège > Centre de recherches du cyclotron
Lemaire, Christian ; Université de Liège - ULiège > Centre de recherches du cyclotron
Collette, Fabienne ; Université de Liège - ULiège > Département de Psychologie : cognition et comportement > Neuropsychologie
Salmon, Eric ; Université de Liège - ULiège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn.
Language :
English
Title :
Episodic autobiographical memory in amnestic Mild Cognitive Impairment: What are the neural correlates?
Addis DR, McIntosh AR, Moscovitch M, Crawley AP, McAndrews MP ( 2004): Characterizing spatial and temporal features of autobiographical memory retrieval networks: A partial least square approach. NeuroImage 23: 1460-1471.
Addis DR, Pan L, Vu M-A, Laiser N, Schacter DL ( 2009a): Constructive episodic simulation of the future and the past: Distinct subsystems of a core brain network mediate imagining and remembering. Neuropsychologia 47: 2222-2238.
Addis DR, Sacchetti DC, Ally BA, Budson AE, Schacter DL ( 2009b): Episodic simulation of future events is impaired in mild Alzheimer's disease. Neuropsychologia 47: 2660-2671.
Alvarez P, Squire LR ( 1994): Memory consolidation and the medial temporal lobe: A simple network model. Proc Natl Acad Sci USA 91: 7041-7045.
Andrés P, Van der Linden M ( 2000): Age-related differences in supervisory attentional system functions. J Gerontol: Psychol Sci 55B: 373-380.
Bastin C, Kerrouche N, Lekeu F, Adam S, Guillaume B, Lemaire C, Aerts J, d'Ydewalle G, Collette F, Salmon E ( 2010): Controlled memory processes in questionable Alzheimer's disease: A view from neuroimaging research. J Alzheimer's Dis 20: 547-560.
Berryhill ME, Phuong L, Picasso L, Cabeza R, Olson IR ( 2007): Parietal lobe and episodic memory: Bilateral damage causes impaired free recall of autobiographical memory. J Neurosci 27: 14415-14423.
Borg C, Thomas-Anterion C, Bogey S, Davier K, Laurent B ( 2010): Visual imagery processing and knowledge of famous names in Alzheimer's disease and MCI. Aging Neuropsychol Cogn 17: 603-14.
Buckner RL, Andrews-Hanna JR, Schacter DL ( 2008): The brain's default network. Ann NY Acad Sci 1124: 1-38.
Burgess PW, Shallice T ( 1996): Confabulation and the control of recollection. Memory 4: 359-411.
Cabeza R ( 2008): Role of parietal regions in episodic memory retrieval: The dual attentional processes hypothesis. Neuropsychologia 46: 1813-1827.
Cabeza R St Jacques P ( 2007): Functional neuroimaging of autobiographical memory. Trend Cogn Sci 11: 219-227.
Chételat G, Desgranges B, De La Sayette V, Viader F, Berkouk K, Landeau B, Lalevée C, Le Doze F, Dupuy B, Hannequin D, Baron JC, Eustache F. ( 2003): Dissociating atrophy and hypometabolism impact on episodic memory in mild cognitive impairment. Brain 126: 1955-1967.
Chételat G, Desgranges B, De La Sayette V, Viader F, Eustache F, Baron JC ( 2002): Mapping gray matter loss with voxel-based morphometry in mild cognitive impairment. NeuroReport 13: 1939-1943.
Ciaramelli E, Grady CL, Moscovitch M. ( 2008): Top-down and bottom-up attention to memory: A hypothesis (AtoM) on the role of the posterior parietal cortex in memory retrieval. Neuropsychologia 46: 1828-1851.
Clare L, Wilson BA, Carter G, Roth I, Hodges JR ( 2002): Assessing awareness in early-stage Alzheimer's disease: Development and piloting of the memory awareness rating scale. Neuropsychol Rehabil 12: 341-362.
Conway MA ( 1996): Autobiographical memories and autobiographical knowledge. In: Rubin DC, editor. Remembering Our Past: Studies of Autobiographical Memories. Cambridge, England: Cambridge University Press. pp 67-93.
Conway MA ( 2009): Episodic memories. Neuropsychologia 47: 2305-2313.
Conway MA, Pleydell-Pearce CW ( 2000): The construction of autobiographical memories in the self-memory system. Psychol Rev 107: 261-288.
Cui X, Jeter CB, Yang D, Montague PR, Eagleman DM ( 2007): Vividness of mental imagery: Individual variability can be measured objectively. Vision Res 47: 474-478.
D'Argembeau A, Van der Linden M ( 2006): Individual differences in the phenomenology of mental time travel: The effect of vivid visual imagery and emotion regulation strategies. Conscious Cogn 15: 342-350.
Daneman M, Carpenter PA ( 1980): Individual differences in working memory and reading. J Verbal Learning Verbal Behav 19: 450-466.
Davidson PSR, Anaki D, Ciaramelli E, Cohn M, Kim ASN, Murphy KJ, Troyer AK, Moscovitch M, Levine B ( 2008): Does lateral parietal cortex support episodic memory? Evidence from focal lesion patients. Neuropsychologia 46: 1743-1755.
de Leon MJ, Desanti S, Zinkowski R, Mehta PD, Pratico D, Segal S, Clark C, Kerkman D, Debernardis J, Li J, Lair L, Reisberg B, Tsui W, Rusinek H( 2004): MRI and CSF studies in the early diagnosis of Alzheimer's disease. J Inter Med 256: 205-223.
Deichmann R, Schwarzbauer C, Turner R ( 2004): Optimisation of the 3D MDEFT sequence for anatomical brain imaging: Technical implications at 1.5 and 3 T. NeuroImage 21: 757-767.
Desmette D, Hupet M, Van der Linden M ( 1995): Adaptation en langue française du "Reading span test" de Daneman et Carpenter (1980). Annee Psychol 95: 459-482.
Fitzgerald JM ( 1988): Vivid memories and the reminiscence phenomenon: The role of self narrative. Hum Dev 31: 261-273.
Fletcher PC, Frith CD, Baker SC, Shallice T, Frackowiak RSJ, Dolan RJ ( 1995): The mind's eye: Precuneus activation in memory-related imagery. NeuroImage 2: 195-200.
Gardiner JM, Java RI, Richardson-Klavehn A ( 1996): How level of processing really influences awareness in recognition memory. Can J Exp Psychol 50: 114-122.
Gardini S, Cornoldi C, De Beni R, Venneri A ( 2006): Left mediotemporal structures mediate the retrieval of episodic autobiographical mental images. NeuroImage 30: 645-655.
Graham KS, Lee ACH, Brett M, Patterson K ( 2003): The neural basis of autobiographical and semantic memory: New evidence from three PET studies. Cogn Affect Behav Neurosci 3: 234-254.
Guedj E, Barbeau EJ, Didic M, Felician O, de Laforte C, Ranjeva JP, Poncet M, Cozzone PJ, Mundler O, Ceccaldi M ( 2009): Effects of medial temporal lobe degeneration on brain perfusion in amnestic MCI of AD type: Deafferentation and functional compensation? Eur J Nucl Med Mol Imaging 36: 1101-1112.
Hassabis D, Maguire EA ( 2007): Deconstructing episodic memory with construction. Trend Cogn Sci 11: 299-306.
Henson RNA, Shallice T, Dolan RJ ( 1999): Right prefrontal cortex and episodic memory retrieval: A functional MRI test of the monitoring hypothesis. Brain 122: 1367-1681.
Irish M, Lawlor BA, O'Mara SM, Coen RF ( 2010): Exploring the recollective experience during autobiographical memory retrieval in amnestic mild cognitive impairment. J Int Neuropsychol Soc 16: 546-555.
Ishai A, Ungerleider LG, Haxby JV ( 2000): Distributed neural systems for the generation of visual images. Neuron 28: 979-990.
Kopelman MD, Kapur N ( 2001): The loss of episodic memories in retrograde amnesia: Single-case and group studies. Philos Trans R Soc London Ser B 356: 1409-1421.
Kopelman MD, Wilson BA, Baddeley AD ( 1989): The autobiographical memory interview: A new assessment of autobiographical and personal semantic memory in amnesic patients. J Clin Exp Neuropsychol 11: 724-744.
Lemaire C, Bamhaut P, Lauricella B, Mosdzianowski C, Morelle JL, Monclus M, Van Naemen J, Mulleneers E, Aerts J, Plenevaux A, Brihaye C, Luxen A ( 2002): Fast [18 F]FDG synthesis by alkaline hydrolysis on a low polarity solid phase support. J Labelled Compd Radiopharm 45: 435-447.
Levine B, Svoboda E, Hay JF, Winocur G, Moscovitch M ( 2002): Aging and autobiographical memory: Dissociating episodic from semantic retrieval. Psychol Aging 17: 677-689.
Leyhe T, Müller S, Milian M, Eschweiler GW, Saur R ( 2009): Impairment of episodic and semantic autobiographical memory in patients with mild cognitive impairment and early Alzheimer's disease. Neuropsychologia 47: 2464-2469.
Maguire EA ( 2001): Neuroimaging studies of autobiographical event memory. Philos Trans R Soc London Ser B 356: 1441-1451.
Masdeu JC, Zubieta JL, Arbizu J ( 2005): Neuroimaging as a marker of the onset and progression of Alzheimer's disease. J Neurol Sci 236: 55-64.
Mattis S ( 1973): Dementia Rating Scale. Windsor, England: NFER-Nelson.
Moscovitch M, Rosenbaum RS, Gilboa A, Addis DR, Westmacott R, Grady C, McAndrews MP, Levine B, Black S, Winocur G, Nadel L( 2005): Functional neuroanatomy of remote episodic, semantic and spatial memory: A unified account based on multiple trace theory. J Anatomy 207: 35-66.
Murphy KJ, Troyer AK, Levine B, Moscovitch M ( 2008): Episodic, but not semantic, autobiographical memory is reduced in amnestic mild cognitive impairment. Neuropsychologia 46: 3116-3123.
Petersen RC, Negash S ( 2008): Mild cognitive impairment: An overview. CNS Spectr 13: 45-53.
Piolino P, Chételat G, Matuszweski V, Landeau B, Mézenge F, Viader F, De La Sayette V, Eustache F, Desgranges B ( 2007): In search of autobiographical memories: A PET study in the frontal variant of frontotemporal dementia. Neuropsychologia 45: 2730-2743.
Piolino P, Desgranges B, Belliard S, Matuszweski V, Lalevée C, De La Sayette V, Eustache F ( 2003): Autobiographical memory and autonoetic consciousness: Triple dissociation in neurodegenerative diseases. Brain 126: 2203-2219.
Piolino P, Desgranges B, Benali K, Eustache F ( 2002): Episodic and semantic remote autobiographical memory in ageing. Memory 10: 239-257.
Piolino P, Desgranges B, Hubert V, Bernard FA, Matuszweski V, Chételat G, Baron JC, Eustache F ( 2008): Reliving lifelong episodic autobiographical memories via the hippocampus: A correlative resting PET study in healthy middle-aged subjects. Hippocampus 18: 445-459.
Quamme JR, Weiss DJ, Norman KA ( 2010): Listening for recollection: A multi-voxel pattern analysis of recognition memory retrieval strategies. Front Hum Neurosci 4: 1-17.
Robinson JA ( 1992): First experience memories: Contexts and function in personal histories. In: Conway MA, Rubin DC, Spinnler H, Wagenaar WA, editors. Theoretical Perspectives on Autobiographical Memory. Dordrecht: Kluwer. pp 223-240.
Salmon E, Lekeu F, Bastin C, Garraux G, Collette F ( 2008): Functional imaging of cognition in Alzheimer's disease using positron emission tomography. Neuropsychologia 46: 1613-1623.
Salmon E, Perani D, Herholz K, Marique P, Kalbe E, Holthoff V, Delbeuck X, Beuthien-Baumann B, Pelati O, Lespagnard S, Collette F, Garraux G( 2006): Neural correlates of anosognosia for cognitive impairment in Alzheimer's disease. Hum Brain Mapping 27: 588-587.
Schacter DL, Addis DR, Buckner RL ( 2007): Remembering the past to imaging the future: The prospective brain. Nat Rev Neurosci 8: 657-661.
Stoub TR, deToledo-Morrell L, Stebbins GT, Leurgans S, Bennett DA, Shah RC ( 2006): Hippocampal disconnection contributes to memory dysfunction in individuals at risk for Alzheimer's disease. Proc Natl Acad Sci 103: 10041-10045.
Svoboda E, Levine B ( 2009): The effects of rehearsal on the functional neuroanatomy of episodic autobiographical and semantic remembering: A functional magnetic resonance imaging study. J Neurosci 29: 3073-3082.
Svoboda E, McKinnon MC, Levine B ( 2006): The functional neuroanatomy of autobiographical memory: A meta-analysis. Neuropsychologia 44: 2189-2208.
Treyer V, Buck A, Schnider A ( 2006): Selection of currently relevant words: An auditory verbal memory study using positron emission tomography. NeuroReport 17: 323-327.
Tulving E ( 1983): Elements of Episodic Memory. Oxford: Oxford University Press.
Viard A, Lebreton K, Chételat G, Desgranges B, Landeau B, Young A, De La Sayette V, Eustache F, Piolino P ( 2010): Patterns of hippocampal-neocortical interactions in the retrieval of episodic autobiographical memories across the entire life-span of aged adults. Hippocampus 20: 153-165.
Yesavage JA, Brink TL, Rose TL, Lum V, Huang V, Adey M, Leier O ( 1983): Development and validation of a geriatric depression screening scale: A preliminary report. J Psychiatr Res 17: 37-49.