References of "Pesesse, Romain"
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See detailTD-GCxGC-HRTOFMS in biological applications 
Focant, Jean-François ULiege; Pesesse, Romain ULiege; Dubois, Lena ULiege et al

Conference (2017, September)

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See detailVOC monitoring by GCxGC-HRTOFMS
Stefanuto, Pierre-Hugues ULiege; Perrault, Katelynn ULiege; Dubois, Lena ULiege et al

Scientific conference (2016, June 02)

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See detailGC×GC-(HR)TOFMS in Cancer Research
Pesesse, Romain ULiege; Stefanuto, Pierre-Hugues ULiege; Bertrand, Virginie ULiege et al

Conference (2016, May 30)

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See detailIn-depth analysis of complex VOC mixtures by GC×GC-HRTOFMS
Focant, Jean-François ULiege; Di Giovanni, Nicolas ULiege; Dubois, Lena ULiege et al

Conference (2016, January)

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See detailExploring the volatome of different cancer cell lines
Stefanuto, Pierre-Hugues ULiege; Pesesse, Romain ULiege; Bertrand, Virginie ULiege et al

in European Respiratory Journal (2015), 46(suppl 59), 3975

As reported by the American Cancer Society, lung cancers have the highest death rate, compared to other types of cancer. The main reason is the lack of early stage non-invasive screening methods. Indeed ... [more ▼]

As reported by the American Cancer Society, lung cancers have the highest death rate, compared to other types of cancer. The main reason is the lack of early stage non-invasive screening methods. Indeed, the death rate of the other most abundant cancers is decreasing due to the implementation of large-scale population screening techniques. It is believed that the death rate of lung cancer could be lowered by developing and implementing more efficient diagnostic methods1. A large number of diseases appear to have a volatile signature present in exhaled air. In practice, analytical breath profiling offers solutions for early detection of different kind of lung infections2. For example, cystic fibrosis patients show a different volatile organic compound (VOC) profile because of the bacterial colonization that localizes in their lungs. A similar behavior is observed for patient suffering from lung cancer. However, the list of recognized volatile biomarkers of lung cancer is still scarce and could be improved. In spite of this, the biological variability of exhaled air profile makes the biomarkers identification challenging. In the hope of contributing to a better understanding, we used comprehensive two-dimensional gas chromatography coupled to time of light mass spectrometry (GC×GC-TOFMS) to investigate the headspace of cancer cells. A procedure has been developed to sample cell culture headspace. After proper data treatment, univariate and multivariate statistics were compared for isolation of potential cancer biomarkers. Further tentative identification was also carried out by using high-accuracy MS analyzers as detection techniques. 1 Siegel, R. et al. Cancer statistics 2013 2 Di Francesco, F. et al. Microchemical Journal 2005 . [less ▲]

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See detailGCxGC-TOFMS and supervised multivariate approaches to study human cadaveric decomposition olfactive signatures
Stefanuto, Pierre-Hugues ULiege; Perrault, Katelynn A.; Stadler, Sonja et al

in Analytical Bioanalytical Chemistry (2015), 407(16), 4767-4778

In forensic thanato-chemistry, the understanding ofthe process of soft tissue decomposition is still limited. Abetter understanding of the decomposition process and thecharacterization of the associated ... [more ▼]

In forensic thanato-chemistry, the understanding ofthe process of soft tissue decomposition is still limited. Abetter understanding of the decomposition process and thecharacterization of the associated volatile organic compounds(VOC) can help to improve the training of victim recovery(VR) canines, which are used to search for trapped victimsin natural disasters or to locate corpses during criminal investigations.The complexity of matrices and the dynamic natureof this process require the use of comprehensive analyticalmethods for investigation. Moreover, the variability of theenvironment and between individuals creates additional difficultiesin terms of normalization. The resolution of the complexmixture of VOCs emitted by a decaying corpse can beimproved using comprehensive two-dimensional gas chromatography(GC× GC), compared to classical singledimensionalgas chromatography (1DGC). This study combinesthe analytical advantages of GC×GC coupled to timeof-flight mass spectrometry (TOFMS) with the data handlingrobustness of supervised multivariate statistics to investigatethe VOC profile of human remains during early stages ofdecomposition. Various supervised multivariate approachesare compared to interpret the large data set. Moreover, earlydecomposition stages of pig carcasses (typically used as humansurrogates in field studies) are also monitored to obtain adirect comparison of the two VOC profiles and estimate therobustness of this human decomposition analog model. In thisresearch, we demonstrate that pig and human decompositionprocesses can be described by the same trends for the majorcompounds produced during the early stages of soft tissuedecomposition. [less ▲]

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See detailReading Cadaveric Decomposition Chemistry with a New Pair of Glasses
Stefanuto, Pierre-Hugues ULiege; Perrault, Katelynn; Stadler, Sonja et al

in CHEMPLUSCHEM (2014), 79(6), 786-789

Smell it out! Thermal desorption has been coupled with comprehensive two-dimensional gas chromatography time of-flight mass spectrometry for the characterization of a cadaveric volatile organic compound ... [more ▼]

Smell it out! Thermal desorption has been coupled with comprehensive two-dimensional gas chromatography time of-flight mass spectrometry for the characterization of a cadaveric volatile organic compound mixture producedduring the active decay stage (see figure). The combined use of the Fisher ratio and principal component analysis provided further characterization of the chemical profile of decomposition. [less ▲]

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See detailTrappist Beers: Exploring the Cloak of Secrecy by GC×GC-TOFMS
Allen, C; Loughnane, C; Stefanuto, Pierre-Hugues ULiege et al

Poster (2014, May 21)

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See detailImproving our vision on human cadaveric decomposition chemistry
Stefanuto, Pierre-Hugues ULiege; Stadler, S; Perrault, K et al

Conference (2014, April 15)

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See detailGC×GC-TOFMS identification of new cadaveric VOCs
Pesesse, Romain ULiege; Stefanuto, Pierre-Hugues ULiege; Stadler, S et al

in Hyphenated Techniques in Chromatography HTC-13 - Book of abstracts (2014, January)

Detailed reference viewed: 51 (7 ULiège)